Amyotrophic Lateral Sclerosis
"Amyotrophic Lateral Sclerosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Descriptor ID |
D000690
|
| MeSH Number(s) |
C10.228.854.139 C10.574.562.250 C10.574.950.050 C10.668.467.250 C18.452.845.800.050
|
| Concept/Terms |
Amyotrophic Lateral Sclerosis- Amyotrophic Lateral Sclerosis
- Sclerosis, Amyotrophic Lateral
- Charcot Disease
- Motor Neuron Disease, Amyotrophic Lateral Sclerosis
- Lou Gehrig Disease
- Lou Gehrig's Disease
- Lou-Gehrigs Disease
- Disease, Lou-Gehrigs
- ALS (Amyotrophic Lateral Sclerosis)
- Gehrig's Disease
- Gehrig Disease
- Gehrigs Disease
Amyotrophic Lateral Sclerosis, Guam Form- Amyotrophic Lateral Sclerosis, Guam Form
- Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam
- Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam
- Guam Form of Amyotrophic Lateral Sclerosis
- Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1
- Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1
- Guam Disease
- Disease, Guam
|
Below are MeSH descriptors whose meaning is more general than "Amyotrophic Lateral Sclerosis".
Below are MeSH descriptors whose meaning is more specific than "Amyotrophic Lateral Sclerosis".
This graph shows the total number of publications written about "Amyotrophic Lateral Sclerosis" by people in this website by year, and whether "Amyotrophic Lateral Sclerosis" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 1 | 2 |
| 2002 | 1 | 1 | 2 |
| 2003 | 2 | 0 | 2 |
| 2004 | 3 | 0 | 3 |
| 2005 | 4 | 1 | 5 |
| 2006 | 1 | 1 | 2 |
| 2008 | 5 | 1 | 6 |
| 2009 | 3 | 0 | 3 |
| 2010 | 2 | 0 | 2 |
| 2011 | 3 | 0 | 3 |
| 2012 | 1 | 0 | 1 |
| 2013 | 3 | 0 | 3 |
| 2014 | 4 | 0 | 4 |
| 2015 | 3 | 0 | 3 |
| 2016 | 4 | 1 | 5 |
| 2017 | 5 | 1 | 6 |
| 2018 | 1 | 0 | 1 |
| 2020 | 4 | 1 | 5 |
| 2021 | 3 | 0 | 3 |
| 2022 | 4 | 0 | 4 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Amyotrophic Lateral Sclerosis" by people in Profiles.
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Exposure to ambient air toxicants and the risk of amyotrophic lateral sclerosis (ALS): A matched case control study. Environ Res. 2024 Feb 01; 242:117719.
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Long-term air pollution and risk of amyotrophic lateral sclerosis mortality in the Women's Health Initiative cohort. Environ Res. 2023 Jan 01; 216(Pt 1):114510.
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Pilot Study of Respiratory-Swallow Coordination in Amyotrophic Lateral Sclerosis. J Speech Lang Hear Res. 2022 08 17; 65(8):2815-2828.
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NR1D1 downregulation in astrocytes induces a phenotype that is detrimental to cocultured motor neurons. FASEB J. 2022 04; 36(4):e22262.
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The BCH message banking process?, voice banking, and double-dipping?. Augment Altern Commun. 2021 12; 37(4):241-250.
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Recruitment of population-based controls for ALS cases from the National ALS Registry. Amyotroph Lateral Scler Frontotemporal Degener. 2021 08; 22(5-6):395-400.
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Letter to the Editor Regarding "Effects of Exercise in Patients With Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis". Am J Phys Med Rehabil. 2021 04 01; 100(4):e55-e56.
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Altered expression of clock and clock-controlled genes in a hSOD1-linked amyotrophic lateral sclerosis mouse model. FASEB J. 2021 02; 35(2):e21343.
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Preface: promoting research in PLS: current knowledge and future challenges. Amyotroph Lateral Scler Frontotemporal Degener. 2020 11; 21(sup1):1-2.
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Effects of RAGE inhibition on the progression of the disease in hSOD1G93A ALS mice. Pharmacol Res Perspect. 2020 08; 8(4):e00636.