Kupffer Cells

"Kupffer Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.

Descriptor ID	D007728
MeSH Number(s)	A11.329.372.588 A11.627.482.588 A11.733.397.588 A15.382.680.397.588 A15.382.812.522.588
Concept/Terms	Kupffer Cells Kupffer Cells Cells, Kupffer

Below are MeSH descriptors whose meaning is more general than "Kupffer Cells".

Anatomy [A]
Cells [A11]
Connective Tissue Cells [A11.329]
Macrophages [A11.329.372]
Kupffer Cells [A11.329.372.588]
Myeloid Cells [A11.627]
Macrophages [A11.627.482]
Kupffer Cells [A11.627.482.588]
Phagocytes [A11.733]
Macrophages [A11.733.397]
Kupffer Cells [A11.733.397.588]
Hemic and Immune Systems [A15]
Immune System [A15.382]
Phagocytes [A15.382.680]
Macrophages [A15.382.680.397]
Kupffer Cells [A15.382.680.397.588]
Mononuclear Phagocyte System [A15.382.812]
Macrophages [A15.382.812.522]
Kupffer Cells [A15.382.812.522.588]

Below are MeSH descriptors whose meaning is related to "Kupffer Cells".

Below are MeSH descriptors whose meaning is more specific than "Kupffer Cells".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Kupffer Cells" by people in this website by year, and whether "Kupffer Cells" was a major or minor topic of these publications.

Bar chart showing 54 publications over 19 distinct years, with a maximum of 7 publications in 1994

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	3	2	5
1994	7	0	7
1995	3	2	5
1996	2	2	4
1997	3	1	4
1998	3	2	5
1999	2	2	4
2000	2	1	3
2001	3	1	4
2002	0	1	1
2003	0	1	1
2004	0	1	1
2007	1	0	1
2010	1	1	2
2011	1	1	2
2014	1	0	1
2015	0	2	2
2018	0	1	1
2019	0	1	1

Below are the most recent publications written about "Kupffer Cells" by people in Profiles.

Albadrani M, Seth RK, Sarkar S, Kimono D, Mondal A, Bose D, Porter DE, Scott GI, Brooks B, Raychoudhury S, Nagarkatti M, Nagarkatti P, Jule Y, Diehl AM, Chatterjee S. Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21. Am J Physiol Gastrointest Liver Physiol. 2019 10 01; 317(4):G408-G428.

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Orr C, Aartun J, Masur H, Kottilil S, Meissner EG. Characterization of changes in intrahepatic immune cell populations during HCV treatment with sofosbuvir and ribavirin. J Viral Hepat. 2019 03; 26(3):323-328.

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Dattaroy D, Seth RK, Das S, Alhasson F, Chandrashekaran V, Michelotti G, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation. Am J Physiol Gastrointest Liver Physiol. 2016 04 01; 310(7):G510-25.

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Lee WJ, Tateya S, Cheng AM, Rizzo-DeLeon N, Wang NF, Handa P, Wilson CL, Clowes AW, Sweet IR, Bomsztyk K, Schwartz MW, Kim F. M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling. Diabetes. 2015 Aug; 64(8):2836-46.

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Sutter AG, Palanisamy AP, Ellet JD, Schmidt MG, Schnellmann RG, Chavin KD. Intereukin-10 and Kupffer cells protect steatotic mice livers from ischemia-reperfusion injury. Eur Cytokine Netw. 2014 Oct-Dec; 25(4):69-76.

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Ellett JD, Atkinson C, Evans ZP, Amani Z, Balish E, Schmidt MG, Schnellmann RG, Chavin KD. Toll-like receptor 4 knockout mice are protected from endothelial overactivation in the absence of Kupffer cells after total hepatic ischemia/reperfusion. Liver Transpl. 2011 Sep; 17(9):1089-98.

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Shao B, Kitchens RL, Munford RS, Rogers TE, Rockey DC, Varley AW. Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin. Hepatology. 2011 Sep 02; 54(3):1051-62.

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Ellett JD, Atkinson C, Evans ZP, Amani Z, Balish E, Schmidt MG, van Rooijen N, Schnellmann RG, Chavin KD. Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10. J Immunol. 2010 May 15; 184(10):5849-58.

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Si-Tayeb K, Lemaigre FP, Duncan SA. Organogenesis and development of the liver. Dev Cell. 2010 Feb 16; 18(2):175-89.

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Shao B, Lu M, Katz SC, Varley AW, Hardwick J, Rogers TE, Ojogun N, Rockey DC, Dematteo RP, Munford RS. A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen. J Biol Chem. 2007 May 04; 282(18):13726-35.

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