Ubiquitin

"Ubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.

Descriptor ID	D025801
MeSH Number(s)	D12.776.947.500
Concept/Terms	Ubiquitin Ubiquitin ATP-Dependent Proteolysis Factor 1 ATP Dependent Proteolysis Factor 1 HMG-20 APF-1 High Mobility Protein 20 Ubiquitin, Human Ubiquitin, Human Human Ubiquitin

Below are MeSH descriptors whose meaning is more general than "Ubiquitin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Ubiquitins [D12.776.947]
Ubiquitin [D12.776.947.500]

Below are MeSH descriptors whose meaning is related to "Ubiquitin".

Below are MeSH descriptors whose meaning is more specific than "Ubiquitin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ubiquitin" by people in this website by year, and whether "Ubiquitin" was a major or minor topic of these publications.

Bar chart showing 48 publications over 18 distinct years, with a maximum of 5 publications in 2005 and 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	2	1	3
2003	2	0	2
2004	2	1	3
2005	1	4	5
2006	2	0	2
2007	4	1	5
2008	0	1	1
2009	2	1	3
2010	1	1	2
2011	1	1	2
2013	2	1	3
2014	1	2	3
2017	3	1	4
2018	2	2	4
2019	0	1	1
2020	0	1	1
2021	2	1	3
2022	0	1	1

Below are the most recent publications written about "Ubiquitin" by people in Profiles.

Howley BV, Mohanty B, Dalton A, Grelet S, Karam J, Dincman T, Howe PH. The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression. Oncogene. 2022 03; 41(12):1679-1690.

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Chan TY, Egbert CM, Maxson JE, Siddiqui A, Larsen LJ, Kohler K, Balasooriya ER, Pennington KL, Tsang TM, Frey M, Soderblom EJ, Geng H, Müschen M, Forostyan TV, Free S, Mercenne G, Banks CJ, Valdoz J, Whatcott CJ, Foulks JM, Bearss DJ, O'Hare T, Huang DCS, Christensen KA, Moody J, Warner SL, Tyner JW, Andersen JL. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nat Commun. 2021 09 09; 12(1):5337.

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Patchett S, Lv Z, Rut W, Békés M, Drag M, Olsen SK, Huang TT. A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease. Cell Rep. 2021 09 28; 36(13):109754.

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Yuan L, Lv Z, Adams MJ, Olsen SK. Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification. Nat Commun. 2021 04 22; 12(1):2370.

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Pan B, Li J, Parajuli N, Tian Z, Wu P, Lewno MT, Zou J, Wang W, Bedford L, Mayer RJ, Fang J, Liu J, Cui T, Su H, Wang X. The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction. Circ Res. 2020 07 31; 127(4):502-518.

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Rycenga HB, Wolfe KB, Yeh ES, Long DT. Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction. Sci Rep. 2019 07 17; 9(1):10329.

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Lv Z, Yuan L, Atkison JH, Williams KM, Vega R, Sessions EH, Divlianska DB, Davies C, Chen Y, Olsen SK. Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme. Nat Commun. 2018 12 04; 9(1):5145.

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Lv Z, Olsen SK. UFM1-Activating Enzyme 5 (Uba5) Requires an Extension to Get the Job Done Right. J Mol Biol. 2019 02 01; 431(3):479-482.

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Lv Z, Williams KM, Yuan L, Atkison JH, Olsen SK. Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity. J Biol Chem. 2018 11 23; 293(47):18337-18352.

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Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD. Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors. PLoS Pathog. 2018 01; 14(1):e1006830.

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