Microphthalmia-Associated Transcription Factor

"Microphthalmia-Associated Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.

Descriptor ID	D051739
MeSH Number(s)	D12.776.260.103.500.500 D12.776.260.108.092.500 D12.776.930.125.500.500 D12.776.930.127.092.500
Concept/Terms	Microphthalmia-Associated Transcription Factor Microphthalmia-Associated Transcription Factor Microphthalmia Associated Transcription Factor Transcription Factor, Microphthalmia-Associated MITF Transcription Factor Transcription Factor Microphthalmia Microphthalmia, Transcription Factor MITF Protein

Below are MeSH descriptors whose meaning is more general than "Microphthalmia-Associated Transcription Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103]
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.260.103.500]
Microphthalmia-Associated Transcription Factor [D12.776.260.103.500.500]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.260.108.092]
Microphthalmia-Associated Transcription Factor [D12.776.260.108.092.500]
Transcription Factors [D12.776.930]
Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125]
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.930.125.500]
Microphthalmia-Associated Transcription Factor [D12.776.930.125.500.500]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.930.127.092]
Microphthalmia-Associated Transcription Factor [D12.776.930.127.092.500]

Below are MeSH descriptors whose meaning is related to "Microphthalmia-Associated Transcription Factor".

Below are MeSH descriptors whose meaning is more specific than "Microphthalmia-Associated Transcription Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Microphthalmia-Associated Transcription Factor" by people in this website by year, and whether "Microphthalmia-Associated Transcription Factor" was a major or minor topic of these publications.

Bar chart showing 18 publications over 12 distinct years, with a maximum of 3 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2001	0	1	1
2002	0	2	2
2003	0	2	2
2006	2	0	2
2007	2	0	2
2009	2	1	3
2011	1	0	1
2013	1	0	1
2016	1	0	1
2017	1	0	1

Below are the most recent publications written about "Microphthalmia-Associated Transcription Factor" by people in Profiles.

Noguchi K, Dalton AC, Howley BV, McCall BJ, Yoshida A, Diehl JA, Howe PH. Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines. PLoS One. 2017; 12(5):e0177830.

View in: PubMed
Carey HA, Bronisz A, Cabrera J, Hildreth BE, Cuitiño M, Fu Q, Ahmad A, Toribio RE, Ostrowski MC, Sharma SM. Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-Eyed Mutant. J Cell Physiol. 2016 Mar; 231(3):630-40.

View in: PubMed
Bronisz A, Carey HA, Godlewski J, Sif S, Ostrowski MC, Sharma SM. The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF). J Biol Chem. 2014 Jan 03; 289(1):326-34.

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Abuzeid M, Dalton SR, Ferringer T, Bernert R, Elston DM. Microphthalmia-associated transcription factor-positive pseudonests in cutaneous lupus erythematosus. Am J Dermatopathol. 2011 Oct; 33(7):752-4.

View in: PubMed
Sharma SM, Sif S, Ostrowski MC, Sankar U. Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice. J Cell Physiol. 2009 Jul; 220(1):230-7.

View in: PubMed
Cronin JC, Wunderlich J, Loftus SK, Prickett TD, Wei X, Ridd K, Vemula S, Burrell AS, Agrawal NS, Lin JC, Banister CE, Buckhaults P, Rosenberg SA, Bastian BC, Pavan WJ, Samuels Y. Frequent mutations in the MITF pathway in melanoma. Pigment Cell Melanoma Res. 2009 Aug; 22(4):435-44.

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Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR. Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res. 2009 Feb 27; 104(4):455-65.

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Sharma SM, Bronisz A, Hu R, Patel K, Mansky KC, Sif S, Ostrowski MC. MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation. J Biol Chem. 2007 May 25; 282(21):15921-9.

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Hu R, Sharma SM, Bronisz A, Srinivasan R, Sankar U, Ostrowski MC. Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors. Mol Cell Biol. 2007 Jun; 27(11):4018-27.

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Meadows NA, Sharma SM, Faulkner GJ, Ostrowski MC, Hume DA, Cassady AI. The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor. J Biol Chem. 2007 Jan 19; 282(3):1891-904.

View in: PubMed

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