Microphthalmia-Associated Transcription Factor
"Microphthalmia-Associated Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.
| Descriptor ID |
D051739
|
| MeSH Number(s) |
D12.776.260.103.500.500 D12.776.260.108.092.500 D12.776.930.125.500.500 D12.776.930.127.092.500
|
| Concept/Terms |
Microphthalmia-Associated Transcription Factor- Microphthalmia-Associated Transcription Factor
- Microphthalmia Associated Transcription Factor
- Transcription Factor, Microphthalmia-Associated
- MITF Transcription Factor
- Transcription Factor Microphthalmia
- Microphthalmia, Transcription Factor
- MITF Protein
|
Below are MeSH descriptors whose meaning is more general than "Microphthalmia-Associated Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Microphthalmia-Associated Transcription Factor".
This graph shows the total number of publications written about "Microphthalmia-Associated Transcription Factor" by people in this website by year, and whether "Microphthalmia-Associated Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 2 | 2 |
| 2006 | 2 | 0 | 2 |
| 2007 | 2 | 0 | 2 |
| 2009 | 2 | 1 | 3 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Microphthalmia-Associated Transcription Factor" by people in Profiles.
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Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines. PLoS One. 2017; 12(5):e0177830.
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Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-Eyed Mutant. J Cell Physiol. 2016 Mar; 231(3):630-40.
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The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF). J Biol Chem. 2014 Jan 03; 289(1):326-34.
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Microphthalmia-associated transcription factor-positive pseudonests in cutaneous lupus erythematosus. Am J Dermatopathol. 2011 Oct; 33(7):752-4.
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Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice. J Cell Physiol. 2009 Jul; 220(1):230-7.
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Frequent mutations in the MITF pathway in melanoma. Pigment Cell Melanoma Res. 2009 Aug; 22(4):435-44.
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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res. 2009 Feb 27; 104(4):455-65.
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Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors. Mol Cell Biol. 2007 Jun; 27(11):4018-27.
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MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation. J Biol Chem. 2007 May 25; 282(21):15921-9.
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The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor. J Biol Chem. 2007 Jan 19; 282(3):1891-904.