Cyclic AMP-Dependent Protein Kinases
"Cyclic AMP-Dependent Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.
| Descriptor ID |
D017868
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.150.125 D12.644.360.200.125 D12.776.476.200.125
|
| Concept/Terms |
Cyclic AMP-Dependent Protein Kinases- Cyclic AMP-Dependent Protein Kinases
- Cyclic AMP Dependent Protein Kinases
- Adenosine Cyclic Monophosphate-Dependent Protein Kinases
- Adenosine Cyclic Monophosphate Dependent Protein Kinases
- cAMP-Dependent Protein Kinase
- Protein Kinase, cAMP-Dependent
- cAMP Dependent Protein Kinase
- cAMP-Dependent Protein Kinases
- Protein Kinases, cAMP-Dependent
- cAMP Dependent Protein Kinases
- Cyclic AMP-Dependent Protein Kinase
- Cyclic AMP Dependent Protein Kinase
- Protein Kinase A
|
Below are MeSH descriptors whose meaning is more general than "Cyclic AMP-Dependent Protein Kinases".
Below are MeSH descriptors whose meaning is more specific than "Cyclic AMP-Dependent Protein Kinases".
This graph shows the total number of publications written about "Cyclic AMP-Dependent Protein Kinases" by people in this website by year, and whether "Cyclic AMP-Dependent Protein Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 0 | 2 |
| 1996 | 0 | 2 | 2 |
| 1997 | 1 | 1 | 2 |
| 1999 | 1 | 1 | 2 |
| 2000 | 1 | 1 | 2 |
| 2002 | 3 | 4 | 7 |
| 2003 | 3 | 3 | 6 |
| 2004 | 1 | 4 | 5 |
| 2005 | 1 | 2 | 3 |
| 2006 | 1 | 5 | 6 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 2 | 2 |
| 2010 | 2 | 4 | 6 |
| 2011 | 3 | 3 | 6 |
| 2012 | 1 | 2 | 3 |
| 2013 | 1 | 2 | 3 |
| 2015 | 2 | 2 | 4 |
| 2016 | 0 | 2 | 2 |
| 2017 | 1 | 2 | 3 |
| 2019 | 3 | 0 | 3 |
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Below are the most recent publications written about "Cyclic AMP-Dependent Protein Kinases" by people in Profiles.
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Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS. Two PKA RIa holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16347-16356.
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Ahuja LG, Aoto PC, Kornev AP, Veglia G, Taylor SS. Dynamic allostery-based molecular workings of kinase:peptide complexes. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15052-15061.
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Wang Y, V S M, Kim J, Li G, Ahuja LG, Aoto P, Taylor SS, Veglia G. Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase's enzymatic cycle. Nat Commun. 2019 02 18; 10(1):799.
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Kelly MP. Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain. Cell Signal. 2018 Jan; 42:281-291.
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Dany M, Elston D. Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa. J Am Acad Dermatol. 2017 Aug; 77(2):268-273.e6.
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Ahuja LG, Kornev AP, McClendon CL, Veglia G, Taylor SS. Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):E931-E940.
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Dany M, Gencer S, Nganga R, Thomas RJ, Oleinik N, Baron KD, Szulc ZM, Ruvolo P, Kornblau S, Andreeff M, Ogretmen B. Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML. Blood. 2016 10 13; 128(15):1944-1958.
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Xin W, Li N, Fernandes VS, Chen B, Rovner ES, Petkov GV. BK channel regulation by phosphodiesterase type 1: a novel signaling pathway controlling human detrusor smooth muscle function. Am J Physiol Renal Physiol. 2016 05 15; 310(10):F994-9.
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Wang L, Tran AB, Nociti FH, Thumbigere-Math V, Foster BL, Krieger CC, Kantovitz KR, Novince CM, Koh AJ, McCauley LK, Somerman MJ. PTH and Vitamin D Repress DMP1 in Cementoblasts. J Dent Res. 2015 Oct; 94(10):1408-16.
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Knape MJ, Ahuja LG, Bertinetti D, Burghardt NC, Zimmermann B, Taylor SS, Herberg FW. Divalent Metal Ions Mg²? and Ca²? Have Distinct Effects on Protein Kinase A Activity and Regulation. ACS Chem Biol. 2015 Oct 16; 10(10):2303-15.