Complement Pathway, Mannose-Binding Lectin
"Complement Pathway, Mannose-Binding Lectin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
| Descriptor ID |
D037582
|
| MeSH Number(s) |
G12.274.849
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| Concept/Terms |
Complement Pathway, Mannose-Binding Lectin- Complement Pathway, Mannose-Binding Lectin
- Complement Pathway, Mannose Binding Lectin
- Lectin-Complement Pathway
- Lectin Complement Pathway
- Lectin-Complement Pathways
- Pathway, Lectin-Complement
- Pathways, Lectin-Complement
- Mannan-Binding Lectin Complement Pathway
- Mannan Binding Lectin Complement Pathway
- Mannose-Binding Lectin Complement Pathway
- Mannose Binding Lectin Complement Pathway
- Mannan-Binding Lectin Pathway (Complement Activation)
- Lectin Pathway, Mannan-Binding (Complement Activation)
- Lectin Pathways, Mannan-Binding (Complement Activation)
- Mannan Binding Lectin Pathway (Complement Activation)
- Mannan-Binding Lectin Pathways (Complement Activation)
- Pathway, Mannan-Binding Lectin (Complement Activation)
- Pathways, Mannan-Binding Lectin (Complement Activation)
|
Below are MeSH descriptors whose meaning is more general than "Complement Pathway, Mannose-Binding Lectin".
Below are MeSH descriptors whose meaning is more specific than "Complement Pathway, Mannose-Binding Lectin".
This graph shows the total number of publications written about "Complement Pathway, Mannose-Binding Lectin" by people in this website by year, and whether "Complement Pathway, Mannose-Binding Lectin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement Pathway, Mannose-Binding Lectin" by people in Profiles.
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Joseph K, Kulik L, Coughlin B, Kunchithapautham K, Bandyopadhyay M, Thiel S, Thielens NM, Holers VM, Rohrer B. Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner. J Biol Chem. 2013 May 03; 288(18):12753-65.
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Elvington A, Atkinson C, Zhu H, Yu J, Takahashi K, Stahl GL, Kindy MS, Tomlinson S. The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012 Nov 01; 189(9):4640-7.