Chloramphenicol O-Acetyltransferase
"Chloramphenicol O-Acetyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
| Descriptor ID |
D015500
|
| MeSH Number(s) |
D08.811.913.050.134.170
|
| Concept/Terms |
Chloramphenicol O-Acetyltransferase- Chloramphenicol O-Acetyltransferase
- Chloramphenicol O Acetyltransferase
- O-Acetyltransferase, Chloramphenicol
- Chloramphenicol Transacetylase
- Transacetylase, Chloramphenicol
- CAT Enzyme
- Enzyme, CAT
- Chloramphenicol Acetyltransferase
- Acetyltransferase, Chloramphenicol
|
Below are MeSH descriptors whose meaning is more general than "Chloramphenicol O-Acetyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Chloramphenicol O-Acetyltransferase".
This graph shows the total number of publications written about "Chloramphenicol O-Acetyltransferase" by people in this website by year, and whether "Chloramphenicol O-Acetyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Chloramphenicol O-Acetyltransferase" by people in Profiles.
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Rapid intranasal delivery of chloramphenicol acetyltransferase in the active form to different brain regions as a model for enzyme therapy in the CNS. J Neurosci Methods. 2016 Feb 01; 259:129-134.
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Expression of two recombinant chloramphenicol acetyltransferase variants in highly reduced genome Escherichia coli strains. Biotechnol Bioeng. 2007 Dec 01; 98(5):1056-70.
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Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-kappaB in adult T-cell leukemia/lymphoma. Leukemia. 2007 Aug; 21(8):1752-62.
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GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis. Stem Cells Dev. 2005 Aug; 14(4):425-39.
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The co-activator p300 associates physically with and can mediate the action of the distal enhancer of the FGF-4 gene. J Biol Chem. 2003 Apr 18; 278(16):13696-705.
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Structured model to predict intracellular amino acid shortages during recombinant protein overexpression in E. coli. J Biotechnol. 2002 Feb 28; 93(3):189-202.
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Isolation and characterization of the murine transforming growth factor-beta2 promoter. Gene. 2001 May 30; 270(1-2):201-9.
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Heat-shock and stringent responses have overlapping protease activity in Escherichia coli. Implications for heterologous protein yield. Appl Biochem Biotechnol. 1999 Apr; 80(1):23-37.
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Inhibitors of protein phosphatase 1 and 2A differentially regulate the expression of inducible nitric-oxide synthase in rat astrocytes and macrophages. J Biol Chem. 1998 May 15; 273(20):12219-26.
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Cytotoxic T lymphocyte responses to proteins encoded by heterologous transgenes transferred in vivo by adenoviral vectors. Hum Gene Ther. 1997 Jul 01; 8(10):1207-17.