"Genes, Suppressor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genes that have a suppressor allele or suppressor mutation (SUPPRESSION, GENETIC) which cancels the effect of a previous mutation, enabling the wild-type phenotype to be maintained or partially restored. For example, amber suppressors cancel the effect of an AMBER NONSENSE MUTATION.
| Descriptor ID |
D016153
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| MeSH Number(s) |
G05.360.340.024.340.460
|
| Concept/Terms |
Genes, Suppressor- Genes, Suppressor
- Gene, Suppressor
- Suppressor Gene
- Second-Site Suppressor Genes
- Second Site Suppressor Genes
- Genes, Second-Site Suppressor
- Gene, Second-Site Suppressor
- Genes, Second Site Suppressor
- Second-Site Suppressor Gene
- Suppressor Gene, Second-Site
- Suppressor Genes, Second-Site
- Suppressor Genes
Genes, Opal Suppressor- Genes, Opal Suppressor
- Gene, Opal Suppressor
- Opal Suppressor Gene
- Opal Suppressor Genes
- Suppressor Gene, Opal
- Suppressor Genes, Opal
Genes, Ochre Suppressor- Genes, Ochre Suppressor
- Gene, Ochre Suppressor
- Ochre Suppressor Gene
- Suppressor Gene, Ochre
- Suppressor Genes, Ochre
- Ochre Suppressor Genes
Genes, Amber Suppressor- Genes, Amber Suppressor
- Amber Suppressor Gene
- Gene, Amber Suppressor
- Suppressor Gene, Amber
- Suppressor Genes, Amber
- Amber Suppressor Genes
Genes, Frameshift Suppressor- Genes, Frameshift Suppressor
- Frameshift Suppressor Gene
- Gene, Frameshift Suppressor
- Suppressor Gene, Frameshift
- Suppressor Genes, Frameshift
- Frameshift Suppressor Genes
|
Below are MeSH descriptors whose meaning is more general than "Genes, Suppressor".
Below are MeSH descriptors whose meaning is more specific than "Genes, Suppressor".
This graph shows the total number of publications written about "Genes, Suppressor" by people in this website by year, and whether "Genes, Suppressor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 0 | 1 |
| 1994 | 0 | 1 | 1 |
| 1995 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 2 | 0 | 2 |
| 2000 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
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Below are the most recent publications written about "Genes, Suppressor" by people in Profiles.
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Primiano T, Baig M, Maliyekkel A, Chang BD, Fellars S, Sadhu J, Axenovich SA, Holzmayer TA, Roninson IB. Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements. Cancer Cell. 2003 Jul; 4(1):41-53.
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Levenson VV, Davidovich IA, Roninson IB. Pleiotropic resistance to DNA-interactive drugs is associated with increased expression of genes involved in DNA replication, repair, and stress response. Cancer Res. 2000 Sep 15; 60(18):5027-30.
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Levenson VV, Lausch E, Kirschling DJ, Broude EV, Davidovich IA, Libants S, Fedosova V, Roninson IB. A combination of genetic suppressor elements produces resistance to drugs inhibiting DNA replication. Somat Cell Mol Genet. 1999 Jan; 25(1):9-26.
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Dunn SJ, Park SW, Sharma V, Raghu G, Simone JM, Tavassoli R, Young LM, Ortega MA, Pan CH, Alegre GJ, Roninson IB, Lipkina G, Dayn A, Holzmayer TA. Isolation of efficient antivirals: genetic suppressor elements against HIV-1. Gene Ther. 1999 Jan; 6(1):130-7.
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Roninson IB, Zuhn D, Ruth A, de Graaf D. Isolation of altered-function mutants and genetic suppressor elements of multidrug transporter P-glycoprotein by expression selection from retroviral libraries. Methods Enzymol. 1998; 292:225-48.
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Gudkov AV, Roninson IB. Isolation of genetic suppressor elements (GSEs) from random fragment cDNA libraries in retroviral vectors. Methods Mol Biol. 1997; 69:221-40.
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Roninson IB, Gudkov AV, Holzmayer TA, Kirschling DJ, Kazarov AR, Zelnick CR, Mazo IA, Axenovich S, Thimmapaya R. Genetic suppressor elements: new tools for molecular oncology--thirteenth Cornelius P. Rhoads Memorial Award Lecture. Cancer Res. 1995 Sep 15; 55(18):4023-8.
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Gudkov AV, Kazarov AR, Thimmapaya R, Axenovich SA, Mazo IA, Roninson IB. Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3744-8.
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Gudkov AV, Zelnick CR, Kazarov AR, Thimmapaya R, Suttle DP, Beck WT, Roninson IB. Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3231-5.
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Holzmayer TA, Pestov DG, Roninson IB. Isolation of dominant negative mutants and inhibitory antisense RNA sequences by expression selection of random DNA fragments. Nucleic Acids Res. 1992 Feb 25; 20(4):711-7.