"Floxuridine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Descriptor ID |
D005467
|
| MeSH Number(s) |
D03.383.742.680.852.300.350 D13.570.230.430.432 D13.570.685.852.300.350
|
| Concept/Terms |
Floxuridine- Floxuridine
- 5-FUdR
- FUdR
- Fluorodeoxyuridine
- 5-Fluorodeoxyuridine
- 5 Fluorodeoxyuridine
|
Below are MeSH descriptors whose meaning is more general than "Floxuridine".
Below are MeSH descriptors whose meaning is more specific than "Floxuridine".
This graph shows the total number of publications written about "Floxuridine" by people in this website by year, and whether "Floxuridine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1995 | 1 | 1 | 2 |
| 1999 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Floxuridine" by people in Profiles.
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Wickremsinhe ER, Lee LB, Schmalz CA, Torchia J, Ruterbories KJ. High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 01; 932:117-22.
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Connelly L, Barham W, Onishko HM, Chen L, Sherrill TP, Zabuawala T, Ostrowski MC, Blackwell TS, Yull FE. NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model. Breast Cancer Res. 2011 Aug 31; 13(4):R83.
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Berger FG, Berger SH. Thymidylate synthase as a chemotherapeutic drug target: where are we after fifty years? Cancer Biol Ther. 2006 Sep; 5(9):1238-41.
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Kobayashi M, Wood PA, Hrushesky WJ. Circadian chemotherapy for gynecological and genitourinary cancers. Chronobiol Int. 2002 Jan; 19(1):237-51.
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Axelson MD, Davis MA, Ethier SP, Lawrence TS. HPV16-E7 expression causes fluorodeoxyuridine-mediated radiosensitization in SW620 human colon cancer cells. Neoplasia. 1999 Jun; 1(2):177-82.
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Wong MK, Bjarnason GA, Hrushesky WJ, Webster P, Morava-Protzner I, Towers M. Steroid-responsive interstitial lung disease in patients receiving 2'-deoxy-5-fluorouridine-infusion chemotherapy. A report of three cases. Cancer. 1995 May 15; 75(10):2558-64.
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Hrushesky WJ. Cancer chronotherapy: is there a right time in the day to treat? J Infus Chemother. 1995; 5(1):38-43.
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Hrushesky WJ. Circadian pharmacodynamics of anticancer therapies. Clin Chem. 1993 Nov; 39(11 Pt 2):2413-8.
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Hrushesky WJ. The multifrequency (circadian, fertility cycle, and season) balance between host and cancer. Ann N Y Acad Sci. 1991; 618:228-56.
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Hrushesky WJ, von Roemeling R, Lanning RM, Rabatin JT. Circadian-shaped infusions of floxuridine for progressive metastatic renal cell carcinoma. J Clin Oncol. 1990 Sep; 8(9):1504-13.