"Floxuridine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Descriptor ID |
D005467
|
| MeSH Number(s) |
D03.383.742.680.852.300.350 D13.570.230.430.432 D13.570.685.852.300.350
|
| Concept/Terms |
Floxuridine- Floxuridine
- 5-FUdR
- FUdR
- Fluorodeoxyuridine
- 5-Fluorodeoxyuridine
- 5 Fluorodeoxyuridine
|
Below are MeSH descriptors whose meaning is more general than "Floxuridine".
Below are MeSH descriptors whose meaning is more specific than "Floxuridine".
This graph shows the total number of publications written about "Floxuridine" by people in this website by year, and whether "Floxuridine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 |
| 1999 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Floxuridine" by people in Profiles.
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High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 01; 932:117-22.
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NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model. Breast Cancer Res. 2011 Aug 31; 13(4):R83.
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Thymidylate synthase as a chemotherapeutic drug target: where are we after fifty years? Cancer Biol Ther. 2006 Sep; 5(9):1238-41.
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HPV16-E7 expression causes fluorodeoxyuridine-mediated radiosensitization in SW620 human colon cancer cells. Neoplasia. 1999 Jun; 1(2):177-82.
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Steroid-responsive interstitial lung disease in patients receiving 2'-deoxy-5-fluorouridine-infusion chemotherapy. A report of three cases. Cancer. 1995 May 15; 75(10):2558-64.
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Cancer chronotherapy: is there a right time in the day to treat? J Infus Chemother. 1995; 5(1):38-43.
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Circadian pharmacodynamics of anticancer therapies. Clin Chem. 1993 Nov; 39(11 Pt 2):2413-8.
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The multifrequency (circadian, fertility cycle, and season) balance between host and cancer. Ann N Y Acad Sci. 1991; 618:228-56.
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Circadian-shaped infusions of floxuridine for progressive metastatic renal cell carcinoma. J Clin Oncol. 1990 Sep; 8(9):1504-13.
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Determination of the therapeutic index of floxuridine by its circadian infusion pattern. J Natl Cancer Inst. 1990 Mar 07; 82(5):386-93.