Growth Differentiation Factor 15

"Growth Differentiation Factor 15" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A growth differentiation factor that is secreted in response to cell stress and in response to MACROPHAGE ACTIVATION. In addition growth differentiation factor 15 demonstrates a diverse array of biological properties including the induction of cartilage formation, the inhibition of hematopoietic progenitor proliferation, and the induction of neuronal migration.

Descriptor ID	D055436
MeSH Number(s)	D12.644.276.374.305 D12.644.276.954.300.915 D12.776.467.374.305 D12.776.467.942.300.915 D23.529.374.305 D23.529.942.300.915
Concept/Terms	Growth Differentiation Factor 15 Growth Differentiation Factor 15 Macrophage Inhibitory Cytokine 1 Prostate Differentiation Factor Differentiation Factor, Prostate GDF-15

Below are MeSH descriptors whose meaning is more general than "Growth Differentiation Factor 15".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Growth Differentiation Factor 15 [D12.644.276.374.305]
TGF-beta Superfamily Proteins [D12.644.276.954]
Growth Differentiation Factors [D12.644.276.954.300]
Growth Differentiation Factor 15 [D12.644.276.954.300.915]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Growth Differentiation Factor 15 [D12.776.467.374.305]
TGF-beta Superfamily Proteins [D12.776.467.942]
Growth Differentiation Factors [D12.776.467.942.300]
Growth Differentiation Factor 15 [D12.776.467.942.300.915]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Growth Differentiation Factor 15 [D23.529.374.305]
TGF-beta Superfamily Proteins [D23.529.942]
Growth Differentiation Factors [D23.529.942.300]
Growth Differentiation Factor 15 [D23.529.942.300.915]

Below are MeSH descriptors whose meaning is more specific than "Growth Differentiation Factor 15".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Growth Differentiation Factor 15" by people in this website by year, and whether "Growth Differentiation Factor 15" was a major or minor topic of these publications.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2013	1	1	2
2016	1	0	1
2017	1	0	1
2018	1	0	1
2019	1	0	1

Below are the most recent publications written about "Growth Differentiation Factor 15" by people in Profiles.

Arif E, Solanki AK, Srivastava P, Rahman B, Tash BR, Holzman LB, Janech MG, Martin R, Knölker HJ, Fitzgibbon WR, Deng P, Budisavljevic MN, Syn WK, Wang C, Lipschutz JH, Kwon SH, Nihalani D. The motor protein Myo1c regulates transforming growth factor-ß-signaling and fibrosis in podocytes. Kidney Int. 2019 07; 96(1):139-158.

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Bouabdallaoui N, Claggett B, Zile MR, McMurray JJV, O'Meara E, Packer M, Prescott MF, Swedberg K, Solomon SD, Rouleau JL. Growth differentiation factor-15 is not modified by sacubitril/valsartan and is an independent marker of risk in patients with heart failure and reduced ejection fraction: the PARADIGM-HF trial. Eur J Heart Fail. 2018 12; 20(12):1701-1709.

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Ratnam NM, Peterson JM, Talbert EE, Ladner KJ, Rajasekera PV, Schmidt CR, Dillhoff ME, Swanson BJ, Haverick E, Kladney RD, Williams TM, Leone GW, Wang DJ, Guttridge DC. NF-?B regulates GDF-15 to suppress macrophage surveillance during early tumor development. J Clin Invest. 2017 Oct 02; 127(10):3796-3809.

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Lindholm D, James SK, Bertilsson M, Becker RC, Cannon CP, Giannitsis E, Harrington RA, Himmelmann A, Kontny F, Siegbahn A, Steg PG, Storey RF, Velders MA, Weaver WD, Wallentin L. Biomarkers and Coronary Lesions Predict Outcomes after Revascularization in Non-ST-Elevation Acute Coronary Syndrome. Clin Chem. 2017 Feb; 63(2):573-584.

View in: PubMed
Wallentin L, Lindholm D, Siegbahn A, Wernroth L, Becker RC, Cannon CP, Cornel JH, Himmelmann A, Giannitsis E, Harrington RA, Held C, Husted S, Katus HA, Mahaffey KW, Steg PG, Storey RF, James SK. Biomarkers in relation to the effects of ticagrelor in comparison with clopidogrel in non-ST-elevation acute coronary syndrome patients managed with or without in-hospital revascularization: a substudy from the Prospective Randomized Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation. 2014 Jan 21; 129(3):293-303.

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Yang CZ, Ma J, Luo QQ, Neskey DM, Zhu DW, Liu Y, Myers JN, Zhang CP, Zhang ZY, Zhong LP. Elevated level of serum growth differentiation factor 15 is associated with oral leukoplakia and oral squamous cell carcinoma. J Oral Pathol Med. 2014 Jan; 43(1):28-34.

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Koopmann J, Buckhaults P, Brown DA, Zahurak ML, Sato N, Fukushima N, Sokoll LJ, Chan DW, Yeo CJ, Hruban RH, Breit SN, Kinzler KW, Vogelstein B, Goggins M. Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers. Clin Cancer Res. 2004 Apr 01; 10(7):2386-92.

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