Cyclin-Dependent Kinase 9

"Cyclin-Dependent Kinase 9" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A multifunctional CDC2 kinase-related kinase that plays roles in transcriptional elongation, CELL DIFFERENTIATION, and APOPTOSIS. It is found associated with CYCLIN T and is a component of POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B.

Descriptor ID	D042863
MeSH Number(s)	D08.811.641.752 D08.811.913.696.620.682.700.646.500.500.750 D12.644.360.250.067.900 D12.776.167.200.067.900 D12.776.476.250.067.900 D12.776.930.955.500.500
Concept/Terms	Cyclin-Dependent Kinase 9 Cyclin-Dependent Kinase 9 Cyclin Dependent Kinase 9 PITALRE Kinase Cdk9 Protein Kinase CDK9 Kinase Cdc2-related Kinase PITALRE Cdc2 related Kinase PITALRE Kinase PITALRE, Cdc2-related PITALRE, Cdc2-related Kinase

Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase 9".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Multifunctional Enzymes [D08.811.641]
Cyclin-Dependent Kinase 9 [D08.811.641.752]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.646.500]
CDC2-CDC28 Kinases [D08.811.913.696.620.682.700.646.500.500]
Cyclin-Dependent Kinase 9 [D08.811.913.696.620.682.700.646.500.500.750]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinases [D12.644.360.250]
CDC2-CDC28 Kinases [D12.644.360.250.067]
Cyclin-Dependent Kinase 9 [D12.644.360.250.067.900]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinases [D12.776.167.200]
CDC2-CDC28 Kinases [D12.776.167.200.067]
Cyclin-Dependent Kinase 9 [D12.776.167.200.067.900]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinases [D12.776.476.250]
CDC2-CDC28 Kinases [D12.776.476.250.067]
Cyclin-Dependent Kinase 9 [D12.776.476.250.067.900]
Transcription Factors [D12.776.930]
Transcriptional Elongation Factors [D12.776.930.955]
Positive Transcriptional Elongation Factor B [D12.776.930.955.500]
Cyclin-Dependent Kinase 9 [D12.776.930.955.500.500]

Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase 9".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclin-Dependent Kinase 9" by people in this website by year, and whether "Cyclin-Dependent Kinase 9" was a major or minor topic of these publications.

Bar chart showing 5 publications over 4 distinct years, with a maximum of 2 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	1	0	1
2012	2	0	2
2015	0	1	1
2018	0	1	1

Below are the most recent publications written about "Cyclin-Dependent Kinase 9" by people in Profiles.

Ivanov A, Lin X, Ammosova T, Ilatovskiy AV, Kumari N, Lassiter H, Afangbedji N, Niu X, Petukhov MG, Nekhai S. HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription. Retrovirology. 2018 05 23; 15(1):39.

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Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S. Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1. Retrovirology. 2015 Jul 16; 12:63.

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Breuer D, Kotelkin A, Ammosova T, Kumari N, Ivanov A, Ilatovskiy AV, Beullens M, Roane PR, Bollen M, Petukhov MG, Kashanchi F, Nekhai S. CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90. Retrovirology. 2012 Nov 09; 9:94.

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Dolloff NG, Allen JE, Dicker DT, Aqui N, Vogl D, Malysz J, Talamo G, El-Deiry WS. Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9. Mol Cancer Ther. 2012 Nov; 11(11):2321-30.

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Wang J, Reuschel EL, Shackelford JM, Jeang L, Shivers DK, Diehl JA, Yu XF, Finkel TH. HIV-1 Vif promotes the G1- to S-phase cell-cycle transition. Blood. 2011 Jan 27; 117(4):1260-9.

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Wang S, Meades C, Wood G, Osnowski A, Anderson S, Yuill R, Thomas M, Mezna M, Jackson W, Midgley C, Griffiths G, Fleming I, Green S, McNae I, Wu SY, McInnes C, Zheleva D, Walkinshaw MD, Fischer PM. 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity. J Med Chem. 2004 Mar 25; 47(7):1662-75.

View in: PubMed

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