"Small Molecule Libraries" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.
| Descriptor ID |
D054852
|
| MeSH Number(s) |
D27.720.470.765
|
| Concept/Terms |
Small Molecule Libraries- Small Molecule Libraries
- Libraries, Small Molecule
- Molecule Libraries, Small
- Molecular Libraries, Small
- Libraries, Small Molecular
- Small Molecular Libraries
- Chemical Libraries
- Libraries, Chemical
|
Below are MeSH descriptors whose meaning is more general than "Small Molecule Libraries".
Below are MeSH descriptors whose meaning is more specific than "Small Molecule Libraries".
This graph shows the total number of publications written about "Small Molecule Libraries" by people in this website by year, and whether "Small Molecule Libraries" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 5 | 6 |
| 2012 | 1 | 0 | 1 |
| 2013 | 5 | 0 | 5 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 1 | 2 |
| 2016 | 3 | 1 | 4 |
| 2017 | 1 | 1 | 2 |
| 2018 | 2 | 1 | 3 |
| 2019 | 2 | 1 | 3 |
| 2020 | 2 | 1 | 3 |
| 2021 | 2 | 1 | 3 |
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Below are the most recent publications written about "Small Molecule Libraries" by people in Profiles.
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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nat Commun. 2021 11 25; 12(1):6896.
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Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells. J Med Chem. 2021 07 22; 64(14):9916-9925.
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Newly Identified Chemicals Preserve Mitochondrial Capacity and Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models. J Ocul Pharmacol Ther. 2021 Jul-Aug; 37(6):367-378.
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Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening. SLAS Discov. 2021 01; 26(1):113-121.
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The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases. Int J Mol Sci. 2020 Mar 19; 21(6).
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Use of Small-molecule Inhibitory Compound of PERK-dependent Signaling Pathway as a Promising Target-based Therapy for Colorectal Cancer. Curr Cancer Drug Targets. 2020; 20(3):223-238.
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Therapeutic targeting of RAS: New hope for drugging the "undruggable". Biochim Biophys Acta Mol Cell Res. 2020 02; 1867(2):118570.
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One Among Millions: The Chemical Space of Nucleic Acid-Like Molecules. J Chem Inf Model. 2019 10 28; 59(10):4266-4277.
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Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death. Cell Chem Biol. 2019 08 15; 26(8):1110-1121.e4.
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Discovery platform for inhibitors of IgH gene enhancer activity. Cancer Biol Ther. 2019; 20(4):571-581.