MAP Kinase Kinase 1

"MAP Kinase Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An abundant 43-kDa mitogen-activated protein kinase kinase subtype with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 1 and MITOGEN-ACTIVATED PROTEIN KINASE 3.

Descriptor ID	D048369
MeSH Number(s)	D08.811.913.696.620.682.700.565.100 D08.811.913.696.620.682.725.200.100 D12.644.360.440.100 D12.776.476.440.100
Concept/Terms	MAP Kinase Kinase 1 MAP Kinase Kinase 1 MKK1 Protein Kinase MAP2K1 Protein Mitogen-Activated Protein Kinase Kinase 1 Mitogen Activated Protein Kinase Kinase 1 MKK-1 Protein Kinase MKK 1 Protein Kinase MEK-1 Protein Kinase MEK 1 Protein Kinase MAPK Kinase 1 MEK1 Protein Kinase

Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase 1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
MAP Kinase Kinase 1 [D08.811.913.696.620.682.700.565.100]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.725.200]
MAP Kinase Kinase 1 [D08.811.913.696.620.682.725.200.100]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinase Kinases [D12.644.360.440]
MAP Kinase Kinase 1 [D12.644.360.440.100]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinase Kinases [D12.776.476.440]
MAP Kinase Kinase 1 [D12.776.476.440.100]

Below are MeSH descriptors whose meaning is related to "MAP Kinase Kinase 1".

Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MAP Kinase Kinase 1" by people in this website by year, and whether "MAP Kinase Kinase 1" was a major or minor topic of these publications.

Bar chart showing 19 publications over 13 distinct years, with a maximum of 3 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1998	0	2	2
1999	0	2	2
2000	0	1	1
2002	0	2	2
2004	0	3	3
2005	1	0	1
2006	1	1	2
2007	1	0	1
2010	0	1	1
2013	0	1	1
2016	1	0	1
2017	1	0	1

Below are the most recent publications written about "MAP Kinase Kinase 1" by people in Profiles.

Andritsos LA, Grieselhuber NR, Anghelina M, Rogers KA, Roychowdhury S, Reeser JW, Timmers CD, Freud AG, Blachly JS, Lucas DM, Lozanski G, Jones JA, Williams K, Oakes C, Jones D, Grever MR. Trametinib for the treatment of IGHV4-34, MAP2K1-mutant variant hairy cell leukemia. Leuk Lymphoma. 2018 04; 59(4):1008-1011.

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Ahn DH, Ozer HG, Hancioglu B, Lesinski GB, Timmers C, Bekaii-Saab T. Whole-exome tumor sequencing study in biliary cancer patients with a response to MEK inhibitors. Oncotarget. 2016 Feb 02; 7(5):5306-12.

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Jang HS, Han SJ, Kim JI, Lee S, Lipschutz JH, Park KM. Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia/reperfusion injury. Biochim Biophys Acta. 2013 Dec; 1832(12):1998-2008.

View in: PubMed
Walker T, Mitchell C, Park MA, Yacoub A, Rahmani M, Häussinger D, Reinehr R, Voelkel-Johnson C, Fisher PB, Grant S, Dent P. 17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species. Mol Cancer Ther. 2010 May; 9(5):1378-95.

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Park ER, Eblen ST, Catling AD. MEK1 activation by PAK: a novel mechanism. Cell Signal. 2007 Jul; 19(7):1488-96.

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Komatsu K, Buchanan FG, Otaka M, Jin M, Odashima M, Horikawa Y, Watanabe S, Dubois RN. Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells. Mol Cancer. 2006 Nov 17; 5:63.

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Jia W, Hegde VL, Singh NP, Sisco D, Grant S, Nagarkatti M, Nagarkatti PS. Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria. Mol Cancer Res. 2006 Aug; 4(8):549-62.

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Komatsu K, Buchanan FG, Katkuri S, Morrow JD, Inoue H, Otaka M, Watanabe S, DuBois RN. Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2. Gastroenterology. 2005 Aug; 129(2):577-90.

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Wang Y, Meng A, Zhou D. Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp Cell Res. 2004 Aug 01; 298(1):188-96.

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O'Brien LE, Tang K, Kats ES, Schutz-Geschwender A, Lipschutz JH, Mostov KE. ERK and MMPs sequentially regulate distinct stages of epithelial tubule development. Dev Cell. 2004 Jul; 7(1):21-32.

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