"MAP Kinase Kinase 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.
| Descriptor ID |
D048670
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.565.400 D08.811.913.696.620.682.725.200.400 D12.644.360.440.400 D12.776.476.440.400
|
| Concept/Terms |
MAP Kinase Kinase 4- MAP Kinase Kinase 4
- JN Kinase Kinase
- JNK Kinase
- Jun Amino-Terminal Kinase Kinase
- Jun Amino Terminal Kinase Kinase
- JNK-Activating Protein Kinase
- JNK Activating Protein Kinase
- Protein Kinase, JNK-Activating
- SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1
- SAP Kinase Extracellular Signal Regulated Kinase Kinase 1
- SEK1 Protein Kinase
- Protein Kinase, SEK1
- Mitogen-Activated Protein Kinase Kinase 4
- Mitogen Activated Protein Kinase Kinase 4
- MEK4 Protein Kinase
- Protein Kinase, MEK4
- JNKK1 Protein Kinase
- Kinase, JNKK1 Protein
- Protein Kinase, JNKK1
- Stress-Activated Protein Kinase Kinase 1
- Stress Activated Protein Kinase Kinase 1
- SAPK-ERK Kinase 1
- SAPK ERK Kinase 1
- SAP Kinase Kinase 1
|
Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase 4".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase 4".
This graph shows the total number of publications written about "MAP Kinase Kinase 4" by people in this website by year, and whether "MAP Kinase Kinase 4" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 2 | 1 | 3 |
| 2000 | 1 | 1 | 2 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "MAP Kinase Kinase 4" by people in Profiles.
-
Inhibition of NFAM1 suppresses phospho-SAPK/JNK signaling during osteoclast differentiation and bone resorption. J Cell Biochem. 2021 10; 122(10):1534-1543.
-
miR155 deficiency aggravates high-fat diet-induced adipose tissue fibrosis in male mice. Physiol Rep. 2017 Sep; 5(18).
-
A Low Dose of Dietary Quercetin Fails to Protect against the Development of an Obese Phenotype in Mice. PLoS One. 2016; 11(12):e0167979.
-
Co-Targeting of JNK and HUNK in Resistant HER2-Positive Breast Cancer. PLoS One. 2016; 11(4):e0153025.
-
Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. J Immunol. 2012 May 01; 188(9):4360-8.
-
A vaccinia virus-driven interplay between the MKK4/7-JNK1/2 pathway and cytoskeleton reorganization. J Virol. 2012 Jan; 86(1):172-84.
-
The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages. Cell Signal. 2012 Feb; 24(2):569-576.
-
Pivotal role of JNK-dependent FOXO1 activation in downregulation of kallistatin expression by oxidative stress. Am J Physiol Heart Circ Physiol. 2010 Mar; 298(3):H1048-54.
-
An emerging role of deubiquitinating enzyme cylindromatosis (CYLD) in the tubulointerstitial inflammation of IgA nephropathy. Biochem Biophys Res Commun. 2009 Dec 11; 390(2):307-12.
-
Insulin-like growth factor-II is increased in systemic sclerosis-associated pulmonary fibrosis and contributes to the fibrotic process via Jun N-terminal kinase- and phosphatidylinositol-3 kinase-dependent pathways. Am J Pathol. 2008 Jun; 172(6):1580-90.