Receptor, Bradykinin B2

"Receptor, Bradykinin B2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A constitutively expressed subtype of bradykinin receptor that may play a role in the acute phase of the inflammatory and pain response. It has high specificity for intact forms of BRADYKININ and KALLIDIN. The receptor is coupled to G-PROTEIN, GQ-G11 ALPHA FAMILY and G-PROTEIN, GI-GO ALPHA FAMILY signaling proteins.

Descriptor ID	D043782
MeSH Number(s)	D12.776.543.750.695.080.500 D12.776.543.750.720.600.220.500 D12.776.543.750.750.555.220.500
Concept/Terms	Receptor, Bradykinin B2 Receptor, Bradykinin B2 B2 Receptor, Bradykinin Receptor, Bradykinin Type 2 Bradykinin Type 2 Receptor Bradykinin B2 Receptors B2 Receptors, Bradykinin Receptors, Bradykinin B2 Bradykinin B2 Receptor

Below are MeSH descriptors whose meaning is more general than "Receptor, Bradykinin B2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, G-Protein-Coupled [D12.776.543.750.695]
Receptors, Bradykinin [D12.776.543.750.695.080]
Receptor, Bradykinin B2 [D12.776.543.750.695.080.500]
Receptors, Neurotransmitter [D12.776.543.750.720]
Receptors, Neuropeptide [D12.776.543.750.720.600]
Receptors, Bradykinin [D12.776.543.750.720.600.220]
Receptor, Bradykinin B2 [D12.776.543.750.720.600.220.500]
Receptors, Peptide [D12.776.543.750.750]
Receptors, Neuropeptide [D12.776.543.750.750.555]
Receptors, Bradykinin [D12.776.543.750.750.555.220]
Receptor, Bradykinin B2 [D12.776.543.750.750.555.220.500]

Below are MeSH descriptors whose meaning is related to "Receptor, Bradykinin B2".

Below are MeSH descriptors whose meaning is more specific than "Receptor, Bradykinin B2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptor, Bradykinin B2" by people in this website by year, and whether "Receptor, Bradykinin B2" was a major or minor topic of these publications.

Bar chart showing 42 publications over 20 distinct years, with a maximum of 6 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	2	2
1996	0	3	3
1997	0	1	1
1998	0	1	1
2000	0	2	2
2001	0	2	2
2002	0	2	2
2003	1	2	3
2004	1	0	1
2005	0	1	1
2006	5	1	6
2007	2	1	3
2008	3	0	3
2009	0	1	1
2010	1	3	4
2011	0	1	1
2013	2	0	2
2014	1	0	1
2015	0	2	2
2019	1	0	1

Below are the most recent publications written about "Receptor, Bradykinin B2" by people in Profiles.

Dagher OK, Jaffa MA, Habib A, Ziyadeh FN, Jaffa AA. Heteromerization fingerprints between bradykinin B2 and thromboxane TP receptors in native cells. PLoS One. 2019; 14(5):e0216908.

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Abou Msallem J, Chalhoub H, Al-Hariri M, Saad L, Jaffa MA, Ziyadeh FN, Jaffa AA. Mechanisms of bradykinin-induced expression of connective tissue growth factor and nephrin in podocytes. Am J Physiol Renal Physiol. 2015 Dec 01; 309(11):F980-90.

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Nokkari A, Mouhieddine TH, Itani MM, Abou-Kheir W, Daoud G, Zhu R, Mechref Y, Meshref Y, Soueid J, Al Hariri M, Mondello S, Jaffa AA, Kobeissy F. Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment. PLoS One. 2015; 10(6):e0128601.

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Sharif NA, Katoli P, Scott D, Li L, Kelly C, Xu S, Husain S, Toris C, Crosson C. FR-190997, a nonpeptide bradykinin B2-receptor partial agonist, is a potent and efficacious intraocular pressure lowering agent in ocular hypertensive cynomolgus monkeys. Drug Dev Res. 2014 Jun; 75(4):211-23.

View in: PubMed
Sharif NA, Xu S, Li L, Katoli P, Kelly CR, Wang Y, Cao S, Patil R, Husain S, Klekar L, Scott D. Protein expression, biochemical pharmacology of signal transduction, and relation to intraocular pressure modulation by bradykinin B2 receptors in ciliary muscle. Mol Vis. 2013; 19:1356-70.

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Wilson PC, Lee MH, Appleton KM, El-Shewy HM, Morinelli TA, Peterson YK, Luttrell LM, Jaffa AA. The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers. J Biol Chem. 2013 Jun 28; 288(26):18872-84.

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Webb JG, Yang X, Crosson CE. Bradykinin activation of extracellular signal-regulated kinases in human trabecular meshwork cells. Exp Eye Res. 2011 Jun; 92(6):495-501.

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Dey M, Baldys A, Sumter DB, Göoz P, Luttrell LM, Raymond JR, Göoz M. Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement. J Pharmacol Exp Ther. 2010 Sep 01; 334(3):775-83.

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Wende AR, Soto J, Olsen CD, Pires KM, Schell JC, Larrieu-Lahargue F, Litwin SE, Kakoki M, Takahashi N, Smithies O, Abel ED. Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice. Endocrinology. 2010 Aug; 151(8):3536-42.

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Kramarenko II, Bunni MA, Raymond JR, Garnovskaya MN. Bradykinin B2 receptor interacts with integrin alpha5beta1 to transactivate epidermal growth factor receptor in kidney cells. Mol Pharmacol. 2010 Jul; 78(1):126-34.

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