"Focal Adhesion Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-receptor protein-tyrosine kinase that is expressed primarily in the BRAIN; OSTEOBLASTS; and LYMPHOID CELLS. In the CENTRAL NERVOUS SYSTEM focal adhesion kinase 2 modulates ION CHANNEL function and MITOGEN-ACTIVATED PROTEIN KINASES activity.
| Descriptor ID |
D051418
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.049.750 D23.050.301.500.600.350 D23.050.705.552.600.350
|
| Concept/Terms |
Focal Adhesion Kinase 2- Focal Adhesion Kinase 2
- RAFTK Protein
- Cell Adhesion Kinase Beta
- Proline-Rich Tyrosine Kinase 2
- Proline Rich Tyrosine Kinase 2
- Related Adhesion Focal Tyrosine Kinase
- CADTK Protein
- Focal Adhesion Kinase Autokinase
- FAK Autokinase
- Calcium-Dependent Protein Tyrosine Kinase
- Calcium Dependent Protein Tyrosine Kinase
- PYK2 Protein Tyrosine Kinase
- Protein Tyrosine Kinase PYK2
|
Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesion Kinase 2".
This graph shows the total number of publications written about "Focal Adhesion Kinase 2" by people in this website by year, and whether "Focal Adhesion Kinase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2015 | 1 | 1 | 2 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Focal Adhesion Kinase 2" by people in Profiles.
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Reversal of maladaptive fibrosis and compromised ventricular function in the pressure overloaded heart by a caveolin-1 surrogate peptide. Lab Invest. 2017 04; 97(4):370-382.
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Dasatinib Attenuates Pressure Overload Induced Cardiac Fibrosis in a Murine Transverse Aortic Constriction Model. PLoS One. 2015; 10(10):e0140273.
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A Dual Role for the Nonreceptor Tyrosine Kinase Pyk2 during the Intracellular Trafficking of Human Papillomavirus 16. J Virol. 2015 Sep; 89(17):9103-14.
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?3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse. PLoS One. 2012; 7(9):e45076.
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Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells. Cell Immunol. 2012 Jan-Feb; 275(1-2):47-54.
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B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. J Biol Chem. 2009 Aug 21; 284(34):22865-77.
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The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. Eur J Immunol. 2006 Aug; 36(8):2235-49.
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N-type Ca2+ channels as scaffold proteins in the assembly of signaling molecules for GABAB receptor effects. J Biol Chem. 2004 Jun 04; 279(23):24649-58.
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The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes. J Biol Chem. 2004 Mar 26; 279(13):12009-19.
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Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. J Biol Chem. 1999 May 14; 274(20):13978-84.