Reduced Folate Carrier Protein
"Reduced Folate Carrier Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed folic acid transporter that functions via an antiporter mechanism which is coupled to the transport of organic phosphates.
| Descriptor ID |
D058978
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| MeSH Number(s) |
D12.776.157.530.450.074.500.299.750 D12.776.157.530.450.162.359 D12.776.157.530.937.622 D12.776.543.550.190.608 D12.776.543.585.450.074.500.224.750 D12.776.543.585.450.162.359 D12.776.543.585.937.743 D23.050.301.500.600.813 D23.050.705.552.600.663
|
| Concept/Terms |
Reduced Folate Carrier Protein- Reduced Folate Carrier Protein
- SLC19a1 Transporter
- Transporter, SLC19a1
- Folate Transporter 1
- Transporter 1, Folate
- SLC19a1 Protein
- Protein, SLC19a1
- Reduced Folate Carrier
- Carrier, Reduced Folate
- Folate Carrier, Reduced
- Solute Carrier Family 19, Member 1
|
Below are MeSH descriptors whose meaning is more general than "Reduced Folate Carrier Protein".
Below are MeSH descriptors whose meaning is more specific than "Reduced Folate Carrier Protein".
This graph shows the total number of publications written about "Reduced Folate Carrier Protein" by people in this website by year, and whether "Reduced Folate Carrier Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Reduced Folate Carrier Protein" by people in Profiles.
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Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia. Pharmacogenet Genomics. 2014 Aug; 24(8):387-96.
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Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study. Cancer Causes Control. 2011 Apr; 22(4):541-52.
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Genes involved with folate uptake and distribution and their association with colorectal cancer risk. Cancer Causes Control. 2010 Apr; 21(4):597-608.
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Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines. Biochem J. 2002 Nov 01; 367(Pt 3):741-50.
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A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. J Biol Chem. 1998 Nov 13; 273(46):30189-98.
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Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells. Adv Enzyme Regul. 1997; 37:59-76.