"Angiotensinogen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver and secreted into blood circulation. Angiotensinogen is the inactive precursor of natural angiotensins. Upon successive enzyme cleavages, angiotensinogen yields angiotensin I, II, and III with amino acids numbered at 10, 8, and 7, respectively.
| Descriptor ID |
D000808
|
| MeSH Number(s) |
D12.644.456.073.070 D12.644.861.020 D12.776.811.070 D12.776.872.020
|
| Concept/Terms |
Angiotensinogen- Angiotensinogen
- Serpin A8
- Renin-Substrate
- Renin Substrate
- Hypertensinogen
- Proangiotensin
|
Below are MeSH descriptors whose meaning is more general than "Angiotensinogen".
Below are MeSH descriptors whose meaning is more specific than "Angiotensinogen".
This graph shows the total number of publications written about "Angiotensinogen" by people in this website by year, and whether "Angiotensinogen" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 1 | 2 |
| 1994 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2013 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Angiotensinogen" by people in Profiles.
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Fitzgibbon WR, Dang Y, Bunni MA, Baicu CF, Zile MR, Mullick AE, Saigusa T. Attenuation of accelerated renal cystogenesis in Pkd1 mice by renin-angiotensin system blockade. Am J Physiol Renal Physiol. 2018 02 01; 314(2):F210-F218.
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Saigusa T, Dang Y, Mullick AE, Yeh ST, Zile MR, Baicu CF, Bell PD. Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model. FASEB J. 2016 Jan; 30(1):370-9.
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Alge JL, Karakala N, Neely BA, Janech MG, Tumlin JA, Chawla LS, Shaw AD, Arthur JM. Association of elevated urinary concentration of renin-angiotensin system components and severe AKI. Clin J Am Soc Nephrol. 2013 Dec; 8(12):2043-52.
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Alge JL, Karakala N, Neely BA, Janech MG, Velez JC, Arthur JM. Urinary angiotensinogen predicts adverse outcomes among acute kidney injury patients in the intensive care unit. Crit Care. 2013 Apr 15; 17(2):R69.
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Ge D, Zhu H, Huang Y, Treiber FA, Harshfield GA, Snieder H, Dong Y. Multilocus analyses of Renin-Angiotensin-aldosterone system gene variants on blood pressure at rest and during behavioral stress in young normotensive subjects. Hypertension. 2007 Jan; 49(1):107-12.
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Wang X, Zhu H, Dong Y, Treiber FA, Snieder H. Effects of angiotensinogen and angiotensin II type I receptor genes on blood pressure and left ventricular mass trajectories in multiethnic youth. Twin Res Hum Genet. 2006 Jun; 9(3):393-402.
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Flesch M, Höper A, Dell'Italia L, Evans K, Bond R, Peshock R, Diwan A, Brinsa TA, Wei CC, Sivasubramanian N, Spinale FG, Mann DL. Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor. Circulation. 2003 Aug 05; 108(5):598-604.
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Busman M, Knapp DR, Schey KL. Observation of large multimers in the electrospray ionization mass spectrometry of peptides. Rapid Commun Mass Spectrom. 1994 Feb; 8(2):211-6.
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Bennett CL, Schrader AP, Morris BJ. Cross-sectional analysis of Met235-->Thr variant of angiotensinogen gene in severe, familial hypertension. Biochem Biophys Res Commun. 1993 Dec 15; 197(2):833-9.
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Schunkert H, Tang SS, Litwin SE, Diamant D, Riegger G, Dzau VJ, Ingelfinger JR. Regulation of intrarenal and circulating renin-angiotensin systems in severe heart failure in the rat. Cardiovasc Res. 1993 May; 27(5):731-5.