"Chlorambucil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
| Descriptor ID |
D002699
|
| MeSH Number(s) |
D02.455.526.728.650.156
|
| Concept/Terms |
Chlorambucil- Chlorambucil
- 4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid
- N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid
- Chloraminophene
- Chlorbutin
|
Below are MeSH descriptors whose meaning is more general than "Chlorambucil".
Below are MeSH descriptors whose meaning is more specific than "Chlorambucil".
This graph shows the total number of publications written about "Chlorambucil" by people in this website by year, and whether "Chlorambucil" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 0 | 1 |
| 2006 | 1 | 1 | 2 |
| 2008 | 2 | 0 | 2 |
| 2012 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Chlorambucil" by people in Profiles.
-
Jespersen C, Soragni E, James Chou C, Arora PS, Dervan PB, Gottesfeld JM. Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells. Bioorg Med Chem Lett. 2012 Jun 15; 22(12):4068-71.
-
Chou CJ, O'Hare T, Lefebvre S, Alvarez D, Tyner JW, Eide CA, Druker BJ, Gottesfeld JM. Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate. PLoS One. 2008; 3(10):e3593.
-
Chou CJ, Farkas ME, Tsai SM, Alvarez D, Dervan PB, Gottesfeld JM. Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia. Mol Cancer Ther. 2008 Apr; 7(4):769-78.
-
Tsai SM, Farkas ME, Chou CJ, Gottesfeld JM, Dervan PB. Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates. Nucleic Acids Res. 2007; 35(1):307-16.
-
Alvarez D, Chou CJ, Latella L, Zeitlin SG, Ku S, Puri PL, Dervan PB, Gottesfeld JM. A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate. Cell Cycle. 2006 Jul; 5(14):1537-48.
-
Clapper ML, Kuzmich S, Seestaller LM, Tew KD. Time course of glutathione S-transferase elevation in Walker mammary carcinoma cells following chlorambucil exposure. Biochem Pharmacol. 1993 Feb 09; 45(3):683-90.
-
Ciaccio PJ, Tew KD, LaCreta FP. Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid. Biochem Pharmacol. 1991 Sep 12; 42(7):1504-7.
-
Schisselbauer JC, Silber R, Papadopoulos E, Abrams K, LaCreta FP, Tew KD. Characterization of glutathione S-transferase expression in lymphocytes from chronic lymphocytic leukemia patients. Cancer Res. 1990 Jun 15; 50(12):3562-8.
-
Fujiwara Y, Sugimoto Y, Kasahara K, Bungo M, Yamakido M, Tew KD, Saijo N. Determinants of drug response in a cisplatin-resistant human lung cancer cell line. Jpn J Cancer Res. 1990 May; 81(5):527-35.
-
Ciaccio PJ, Tew KD, LaCreta FP. The spontaneous and glutathione S-transferase-mediated reaction of chlorambucil with glutathione. Cancer Commun. 1990; 2(8):279-85.