Nitrogen Mustard Compounds
"Nitrogen Mustard Compounds" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
| Descriptor ID |
D009588
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| MeSH Number(s) |
D02.455.526.728.650
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Nitrogen Mustard Compounds".
Below are MeSH descriptors whose meaning is more specific than "Nitrogen Mustard Compounds".
This graph shows the total number of publications written about "Nitrogen Mustard Compounds" by people in this website by year, and whether "Nitrogen Mustard Compounds" was a major or minor topic of these publications.
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Below are the most recent publications written about "Nitrogen Mustard Compounds" by people in Profiles.
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Molecular conformation of estramustine and two analogues. Mol Pharmacol. 1992 Mar; 41(3):569-76.
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Intracellular effects of estramustine (Estracyt/Emcyt). Prog Clin Biol Res. 1989; 303:169-75.
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Estramustine--a nitrogen mustard/steroid with antimicrotubule activity. Pharmacol Ther. 1989; 43(3):299-319.
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Estramustine binds a MAP-1-like protein to inhibit microtubule assembly in vitro and disrupt microtubule organization in DU 145 cells. J Cell Biol. 1988 Dec; 107(6 Pt 2):2647-56.
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Estramustine binds MAP-2 to inhibit microtubule assembly in vitro. J Cell Sci. 1988 Mar; 89 ( Pt 3):331-42.
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Immunofluorescent studies of the anti-microtubule effects of the anti-cancer drug estramustine. Anticancer Res. 1987 Nov-Dec; 7(6):1165-71.
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Hormone-independent, non-alkylating mechanism of cytotoxicity for estramustine. Urol Res. 1987; 15(3):155-60.
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Relationship of glutathione depletion and inhibition of glutathione-S-transferase activity to the antimitotic properties of estramustine. Cancer Treat Rep. 1986 Jun; 70(6):715-20.
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Dansylated estramustine, a fluorescent probe for studies of estramustine uptake and identification of intracellular targets. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8483-7.
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Antimicrotubule effects of estramustine, an antiprostatic tumor drug. Cancer Res. 1985 Aug; 45(8):3891-7.