"Mechlorethamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
| Descriptor ID |
D008466
|
| MeSH Number(s) |
D02.455.526.728.650.529
|
| Concept/Terms |
Mechlorethamine- Mechlorethamine
- Chlormethine
- Bis(2-chloroethyl)methylamine
- Mustine
- Nitrogen Mustard
- Chlorethazine
- Methylchlorethamine
Mechlorethamine Hydrochloride N-Oxide- Mechlorethamine Hydrochloride N-Oxide
- Hydrochloride N-Oxide, Mechlorethamine
- Mechlorethamine Hydrochloride N Oxide
- N-Oxide, Mechlorethamine Hydrochloride
Mechlorethamine N-Oxide- Mechlorethamine N-Oxide
- Mechlorethamine N Oxide
- Nitrogen Mustard N-Oxide
- N-Oxide, Nitrogen Mustard
- Nitrogen Mustard N Oxide
|
Below are MeSH descriptors whose meaning is more general than "Mechlorethamine".
Below are MeSH descriptors whose meaning is more specific than "Mechlorethamine".
This graph shows the total number of publications written about "Mechlorethamine" by people in this website by year, and whether "Mechlorethamine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mechlorethamine" by people in Profiles.
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The evolving role of DNA inter-strand crosslinks in chemotherapy. Curr Opin Pharmacol. 2018 08; 41:20-26.
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Double high-dose chemotherapy with stem cell rescue (HD-SCR) in patients with breast cancer - effect of sequence. Cancer Chemother Pharmacol. 2000; 45(3):239-46.
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Therapeutic approaches in cutaneous lymphoma. Dermatol Clin. 1994 Apr; 12(2):433-41.
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Molecular conformation of estramustine and two analogues. Mol Pharmacol. 1992 Mar; 41(3):569-76.
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Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines. Mol Pharmacol. 1987 Jun; 31(6):575-8.
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Differences in the nuclear matrix phosphoproteins of a wild-type and nitrogen mustard-resistant rat breast carcinoma cell line. Cancer Res. 1986 Sep; 46(9):4672-6.
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Selection of nitrogen mustard resistance in a rat tumor cell line results in loss of guanine-O6-alkyl transferase activity. Mol Pharmacol. 1986 Jul; 30(1):77-80.
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A comparative analysis of drug-induced DNA effects in a nitrogen mustard resistant cell line expressing sensitivity to nitrosoureas. Biochem Pharmacol. 1986 Apr 01; 35(7):1171-6.
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Poly(adenosine diphosphate-ribosylation) of nuclear matrix proteins in alkylating agent resistant and sensitive cell lines. Chem Biol Interact. 1985 Jul; 54(2):209-22.