Major Histocompatibility Complex

"Major Histocompatibility Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.

Descriptor ID	D008285
MeSH Number(s)	G05.360.340.024.340.610 G05.360.340.024.380.500 G12.500.500
Concept/Terms	Major Histocompatibility Complex Major Histocompatibility Complex Complex, Major Histocompatibility Complices, Major Histocompatibility Histocompatibility Complex, Major Histocompatibility Complices, Major Major Histocompatibility Complices Histocompatibility Complex Complex, Histocompatibility Complices, Histocompatibility Histocompatibility Complices

Below are MeSH descriptors whose meaning is more general than "Major Histocompatibility Complex".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genes [G05.360.340.024.340]
Major Histocompatibility Complex [G05.360.340.024.340.610]
Genetic Loci [G05.360.340.024.380]
Major Histocompatibility Complex [G05.360.340.024.380.500]
Immune System Phenomena [G12]
Immunogenetic Phenomena [G12.500]
Major Histocompatibility Complex [G12.500.500]

Below are MeSH descriptors whose meaning is related to "Major Histocompatibility Complex".

Below are MeSH descriptors whose meaning is more specific than "Major Histocompatibility Complex".

Major Histocompatibility Complex
Genes, MHC Class I
Genes, MHC Class II

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Major Histocompatibility Complex" by people in this website by year, and whether "Major Histocompatibility Complex" was a major or minor topic of these publications.

Bar chart showing 29 publications over 20 distinct years, with a maximum of 3 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	0	1
1995	1	0	1
1996	1	1	2
1997	0	1	1
1998	1	0	1
2002	0	2	2
2003	0	1	1
2004	0	1	1
2005	2	0	2
2006	0	1	1
2007	0	1	1
2008	1	1	2
2009	1	1	2
2011	0	2	2
2012	3	0	3
2013	1	0	1
2015	1	0	1
2018	2	0	2
2019	1	0	1
2022	0	1	1

Below are the most recent publications written about "Major Histocompatibility Complex" by people in Profiles.

Vyse TJ, Tsao BP. Complement C4, the Major Histocompatibility Complex, and Autoimmunity. Arthritis Rheumatol. 2022 08; 74(8):1318-1320.

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Khan MAW, Stephens WZ, Mohammed AD, Round JL, Kubinak JL. Does MHC heterozygosity influence microbiota form and function? PLoS One. 2019; 14(5):e0215946.

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Hanscombe KB, Morris DL, Noble JA, Dilthey AT, Tombleson P, Kaufman KM, Comeau M, Langefeld CD, Alarcon-Riquelme ME, Gaffney PM, Jacob CO, Sivils KL, Tsao BP, Alarcon GS, Brown EE, Croker J, Edberg J, Gilkeson G, James JA, Kamen DL, Kelly JA, McCune J, Merrill JT, Petri M, Ramsey-Goldman R, Reveille JD, Salmon JE, Scofield H, Utset T, Wallace DJ, Weisman MH, Kimberly RP, Harley JB, Lewis CM, Criswell LA, Vyse TJ. Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans. Hum Mol Genet. 2018 11 01; 27(21):3813-3824.

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Cornwall DH, Kubinak JL, Zachary E, Stark DL, Seipel D, Potts WK. Experimental manipulation of population-level MHC diversity controls pathogen virulence evolution in Mus musculus. J Evol Biol. 2018 02; 31(2):314-322.

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Kubinak JL, Stephens WZ, Soto R, Petersen C, Chiaro T, Gogokhia L, Bell R, Ajami NJ, Petrosino JF, Morrison L, Potts WK, Jensen PE, O'Connell RM, Round JL. MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection. Nat Commun. 2015 Oct 23; 6:8642.

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Kubinak JL, Ruff JS, Cornwall DH, Middlebrook EA, Hasenkrug KJ, Potts WK. Experimental viral evolution reveals major histocompatibility complex polymorphisms as the primary host factors controlling pathogen adaptation and virulence. Genes Immun. 2013 Sep; 14(6):365-72.

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Dong H, Fahmy TM, Metcalfe SM, Morton SL, Dong X, Inverardi L, Adams DB, Gao W, Wang H. Immuno-isolation of pancreatic islet allografts using pegylated nanotherapy leads to long-term normoglycemia in full MHC mismatch recipient mice. PLoS One. 2012; 7(12):e50265.

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Kubinak JL, Ruff JS, Hyzer CW, Slev PR, Potts WK. Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3422-7.

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Ruff JS, Nelson AC, Kubinak JL, Potts WK. MHC signaling during social communication. Adv Exp Med Biol. 2012; 738:290-313.

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Alekseyenko AV, Lytkin NI, Ai J, Ding B, Padyukov L, Aliferis CF, Statnikov A. Causal graph-based analysis of genome-wide association data in rheumatoid arthritis. Biol Direct. 2011 May 18; 6:25.

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