"ras Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.
| Descriptor ID |
D018631
|
| MeSH Number(s) |
D08.811.277.040.330.300.400.500 D12.644.360.525.500 D12.776.157.325.515.500 D12.776.476.525.500
|
| Concept/Terms |
ras Proteins- ras Proteins
- ras GTPases
- GTPases, ras
- Gene Products, ras
- ras Gene Products
|
Below are MeSH descriptors whose meaning is more general than "ras Proteins".
Below are MeSH descriptors whose meaning is more specific than "ras Proteins".
This graph shows the total number of publications written about "ras Proteins" by people in this website by year, and whether "ras Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 2 | 2 | 4 |
| 1997 | 4 | 0 | 4 |
| 1998 | 0 | 2 | 2 |
| 1999 | 1 | 1 | 2 |
| 2000 | 1 | 0 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2005 | 3 | 4 | 7 |
| 2006 | 1 | 2 | 3 |
| 2007 | 2 | 1 | 3 |
| 2008 | 0 | 3 | 3 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 1 | 3 |
| 2011 | 0 | 2 | 2 |
| 2012 | 5 | 4 | 9 |
| 2013 | 3 | 2 | 5 |
| 2014 | 0 | 2 | 2 |
| 2015 | 3 | 2 | 5 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 3 | 2 | 5 |
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Below are the most recent publications written about "ras Proteins" by people in Profiles.
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Weber SM, Brossier NM, Prechtl A, Barnes S, Wilson LS, Brosius SN, Longo JF, Carroll SL. R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. Cell Commun Signal. 2021 09 16; 19(1):95.
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Whaby M, Khan I, O'Bryan JP. Targeting the "undruggable" RAS with biologics. Adv Cancer Res. 2022; 153:237-266.
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Longo JF, Carroll SL. The RASopathies: Biology, genetics and therapeutic options. Adv Cancer Res. 2022; 153:305-341.
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Weber SM, Carroll SL. The Role of R-Ras Proteins in Normal and Pathologic Migration and Morphologic Change. Am J Pathol. 2021 09; 191(9):1499-1510.
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Khan I, O'Bryan JP. Probing RAS Function with Monobodies. Methods Mol Biol. 2021; 2262:281-302.
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Zuberi M, Khan I, O'Bryan JP. Inhibition of RAS: proven and potential vulnerabilities. Biochem Soc Trans. 2020 10 30; 48(5):1831-1841.
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Rhett JM, Khan I, O'Bryan JP. Biology, pathology, and therapeutic targeting of RAS. Adv Cancer Res. 2020; 148:69-146.
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Khan I, Rhett JM, O'Bryan JP. Therapeutic targeting of RAS: New hope for drugging the "undruggable". Biochim Biophys Acta Mol Cell Res. 2020 02; 1867(2):118570.
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Longo JF, Brosius SN, Black L, Worley SH, Wilson RC, Roth KA, Carroll SL. ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms. Cell Commun Signal. 2019 07 10; 17(1):74.
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Wang JC, Lee JY, Dang-Lawson M, Pritchard C, Gold MR. The Rap2c GTPase facilitates B cell receptor-induced reorientation of the microtubule-organizing center. Small GTPases. 2020 11; 11(6):402-412.