Transforming Growth Factor alpha

"Transforming Growth Factor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.

Descriptor ID	D016211
MeSH Number(s)	D12.644.276.382.750 D12.644.276.963.360 D12.776.467.382.750 D12.776.467.960.360 D23.529.382.750 D23.529.960.360
Concept/Terms	Transforming Growth Factor alpha Transforming Growth Factor alpha TGF-alpha TGFalpha Epidermal Growth Factor-Related Transforming Growth Factor Epidermal Growth Factor Related Transforming Growth Factor

Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor alpha".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
EGF Family of Proteins [D12.644.276.382]
Transforming Growth Factor alpha [D12.644.276.382.750]
Transforming Growth Factors [D12.644.276.963]
Transforming Growth Factor alpha [D12.644.276.963.360]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
EGF Family of Proteins [D12.776.467.382]
Transforming Growth Factor alpha [D12.776.467.382.750]
Transforming Growth Factors [D12.776.467.960]
Transforming Growth Factor alpha [D12.776.467.960.360]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
EGF Family of Proteins [D23.529.382]
Transforming Growth Factor alpha [D23.529.382.750]
Transforming Growth Factors [D23.529.960]
Transforming Growth Factor alpha [D23.529.960.360]

Below are MeSH descriptors whose meaning is related to "Transforming Growth Factor alpha".

Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor alpha".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transforming Growth Factor alpha" by people in this website by year, and whether "Transforming Growth Factor alpha" was a major or minor topic of these publications.

Bar chart showing 22 publications over 15 distinct years, with a maximum of 3 publications in 1995 and 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	0	1
1995	2	1	3
1996	0	1	1
1997	0	1	1
1998	1	0	1
2000	1	1	2
2001	1	0	1
2002	1	0	1
2004	1	1	2
2006	0	1	1
2007	3	0	3
2013	0	2	2
2014	0	1	1
2016	0	1	1
2017	0	1	1

Below are the most recent publications written about "Transforming Growth Factor alpha" by people in Profiles.

Chulkina M, Negmadjanov U, Lebedeva E, Pichugin A, Mazurov D, Ataullakhanov R, Holmuhamedov E. Synthetic peptide TEKKRRETVEREKE derived from ezrin induces differentiation of NIH/3T3 fibroblasts. Eur J Pharmacol. 2017 Sep 15; 811:249-259.

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Liu X, Pitarresi JR, Cuitiño MC, Kladney RD, Woelke SA, Sizemore GM, Nayak SG, Egriboz O, Schweickert PG, Yu L, Trela S, Schilling DJ, Halloran SK, Li M, Dutta S, Fernandez SA, Rosol TJ, Lesinski GB, Shakya R, Ludwig T, Konieczny SF, Leone G, Wu J, Ostrowski MC. Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. Genes Dev. 2016 09 01; 30(17):1943-55.

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Beck Gooz M, Maldonado EN, Dang Y, Amria MY, Higashiyama S, Abboud HE, Lemasters JJ, Bell PD. ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease. Am J Physiol Renal Physiol. 2014 Sep 01; 307(5):F551-9.

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Yan F, Liu L, Dempsey PJ, Tsai YH, Raines EW, Wilson CL, Cao H, Cao Z, Liu L, Polk DB. A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. J Biol Chem. 2013 Oct 18; 288(42):30742-30751.

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Byer SJ, Brossier NM, Peavler LT, Eckert JM, Watkins S, Roth KA, Carroll SL. Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands. J Neuropathol Exp Neurol. 2013 Mar; 72(3):219-33.

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Booth BW, Smith GH. Roles of transforming growth factor-alpha in mammary development and disease. Growth Factors. 2007 Aug; 25(4):227-35.

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Booth BW, Sandifer T, Martin EL, Martin LD. IL-13-induced proliferation of airway epithelial cells: mediation by intracellular growth factor mobilization and ADAM17. Respir Res. 2007 Jul 09; 8:51.

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Booth BW, Jhappan C, Merlino G, Smith GH. TGFbeta1 and TGFalpha contrarily affect alveolar survival and tumorigenesis in mouse mammary epithelium. Int J Cancer. 2007 Feb 01; 120(3):493-9.

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Mukhin YV, Gooz M, Raymond JR, Garnovskaya MN. Collagenase-2 and -3 mediate epidermal growth factor receptor transactivation by bradykinin B2 receptor in kidney cells. J Pharmacol Exp Ther. 2006 Sep; 318(3):1033-43.

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Organ EL, Nalbantyan CD, Nanney LB, Woodward SC, Sheng J, Dubois RN, Price J, Sutcliffe M, Coffey RJ, Rubin DH. Effects of transforming growth factor-alpha (TGF-alpha) in vitro and in vivo on reovirus replication. DNA Cell Biol. 2004 Jul; 23(7):430-41.

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