Heparin-binding EGF-like Growth Factor
"Heparin-binding EGF-like Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.
| Descriptor ID |
D066257
|
| MeSH Number(s) |
D12.644.276.382.625 D12.776.467.382.625 D23.529.382.625
|
| Concept/Terms |
Short Form HB-EGF- Short Form HB-EGF
- HB-EGF, Short Form
- Short Form HB EGF
- SF HB-EGF
- SF HB EGF
Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein- Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein
- Heparin binding Epidermal Growth Factor like Growth Factor Precursor Protein
- Receptor, Diphtheria Toxin
- HB-EGF Precursor
- HB EGF Precursor
- Diphtheria Toxin Receptor
- Toxin Receptor, Diphtheria
- Diphtheria Toxin Receptors
- Receptors, Diphtheria Toxin
- Toxin Receptors, Diphtheria
|
Below are MeSH descriptors whose meaning is more general than "Heparin-binding EGF-like Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Heparin-binding EGF-like Growth Factor".
This graph shows the total number of publications written about "Heparin-binding EGF-like Growth Factor" by people in this website by year, and whether "Heparin-binding EGF-like Growth Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Heparin-binding EGF-like Growth Factor" by people in Profiles.
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iRhom2 promotes lupus nephritis through TNF-a and EGFR signaling. J Clin Invest. 2018 04 02; 128(4):1397-1412.
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Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017 Jul; 13(7):727-738.
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ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease. Am J Physiol Renal Physiol. 2014 Sep 01; 307(5):F551-9.
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A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. J Biol Chem. 2013 Oct 18; 288(42):30742-30751.
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Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev. 2013 Apr-May; 130(4-5):272-89.
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A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by a5?1 integrin in kidney mesangial cells. PLoS One. 2012; 7(3):e33350.
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Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit. Gastroenterology. 2010 Jul; 139(1):239-48.
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Urine markers do not predict biopsy findings or presence of bladder ulcers in interstitial cystitis/painful bladder syndrome. J Urol. 2008 May; 179(5):1850-6.
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5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells. J Biol Chem. 2006 Jul 28; 281(30):21004-21012.
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Comparison of APF activity and epithelial growth factor levels in urine from Chinese, African-American, and white American patients with interstitial cystitis. Urology. 2003 May; 61(5):897-901.