"EGF Family of Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that are related to epidermal growth factor. They share in common a consensus sequence consisting of six spatially conserved CYSTEINE residues which form three intramolecular bonds. This consensus sequence is commonly referred to EGF motif and is considered essential for binding of the proteins to ERB RECEPTORS.
| Descriptor ID |
D066255
|
| MeSH Number(s) |
D12.644.276.382 D12.776.467.382 D23.529.382
|
| Concept/Terms |
EGF Family of Proteins- EGF Family of Proteins
- Proteins EGF Family
- Epidermal Growth Factors
- EGF Receptor Ligands
- Ligands, EGF Receptor
- Receptor Ligands, EGF
- Epidermal Growth Factor-Like Proteins
- Epidermal Growth Factor Like Proteins
|
Below are MeSH descriptors whose meaning is more general than "EGF Family of Proteins".
Below are MeSH descriptors whose meaning is more specific than "EGF Family of Proteins".
This graph shows the total number of publications written about "EGF Family of Proteins" by people in this website by year, and whether "EGF Family of Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "EGF Family of Proteins" by people in Profiles.
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Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer. Mol Oncol. 2015 Feb; 9(2):527-43.
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Amphiregulin stimulates liver regeneration after small-for-size mouse liver transplantation. Am J Transplant. 2012 Aug; 12(8):2052-61.
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Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer. J Cell Physiol. 2011 Oct; 226(10):2691-701.
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Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors. J Biol Chem. 2010 Nov 05; 285(45):35206-15.
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Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics. Exp Cell Res. 2010 Feb 01; 316(3):422-32.
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Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor. Biochemistry. 2009 Feb 24; 48(7):1462-73.
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Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop. Cell Signal. 2009 Feb; 21(2):212-9.
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Amphiregulin as a novel target for breast cancer therapy. J Mammary Gland Biol Neoplasia. 2008 Jun; 13(2):171-9.
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Activation of a nuclear factor kappaB/interleukin-1 positive feedback loop by amphiregulin in human breast cancer cells. Mol Cancer Res. 2007 Aug; 5(8):847-61.
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Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells. J Biol Chem. 2006 Dec 08; 281(49):37728-37.