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Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.

Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse. J Clin Invest. 2013 Oct; 123(10):4344-58.

View in: PubMed

subject areas
  • Acid Ceramidase
  • Amides
  • Animals
  • Cell Line, Tumor
  • Enzyme Induction
  • Gene Expression
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Injections, Intraperitoneal
  • Male
  • Mice
  • Mice, Nude
  • Neoplasm Recurrence, Local
  • Promoter Regions, Genetic
  • Propanolamines
  • Prostatic Neoplasms
  • Protein Binding
  • Proto-Oncogene Proteins c-jun
  • Radiation Tolerance
  • Radiation-Sensitizing Agents
  • Sphingolipids
  • Transcription Factor AP-1
  • Transcriptional Activation
  • Xenograft Model Antitumor Assays

authors with profiles
  • Joseph C. Cheng
  • Richard R. Drake
  • Kent E. Armeson
  • David T. Marshall
  • Aiping Bai
  • James S. Norris
  • Thomas E. Keane