"Protein Binding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
| Descriptor ID |
D011485
|
| MeSH Number(s) |
G02.111.679 G03.808
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Protein Binding".
Below are MeSH descriptors whose meaning is more specific than "Protein Binding".
This graph shows the total number of publications written about "Protein Binding" by people in this website by year, and whether "Protein Binding" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 8 | 8 |
| 1995 | 0 | 10 | 10 |
| 1996 | 0 | 18 | 18 |
| 1997 | 0 | 7 | 7 |
| 1998 | 0 | 12 | 12 |
| 1999 | 0 | 15 | 15 |
| 2000 | 2 | 13 | 15 |
| 2001 | 0 | 18 | 18 |
| 2002 | 1 | 13 | 14 |
| 2003 | 0 | 35 | 35 |
| 2004 | 1 | 35 | 36 |
| 2005 | 0 | 31 | 31 |
| 2006 | 0 | 35 | 35 |
| 2007 | 1 | 31 | 32 |
| 2008 | 0 | 28 | 28 |
| 2009 | 0 | 37 | 37 |
| 2010 | 1 | 29 | 30 |
| 2011 | 0 | 32 | 32 |
| 2012 | 0 | 31 | 31 |
| 2013 | 0 | 37 | 37 |
| 2014 | 0 | 28 | 28 |
| 2015 | 0 | 40 | 40 |
| 2016 | 0 | 34 | 34 |
| 2017 | 0 | 37 | 37 |
| 2018 | 1 | 16 | 17 |
| 2019 | 0 | 31 | 31 |
| 2020 | 0 | 13 | 13 |
| 2021 | 0 | 19 | 19 |
| 2022 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Protein Binding" by people in Profiles.
-
Fuzzy supertertiary interactions within PSD-95 enable ligand binding. Elife. 2022 09 07; 11.
-
IGF-dependent dynamic modulation of a protease cleavage site in the intrinsically disordered linker domain of human IGFBP2. Proteins. 2022 09; 90(9):1732-1743.
-
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nat Commun. 2021 11 25; 12(1):6896.
-
Structure-Function Analysis of Two Interacting Vaccinia Proteins That Are Critical for Viral Morphogenesis: L2 and A30.5. J Virol. 2022 01 26; 96(2):e0157721.
-
TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nat Commun. 2021 09 09; 12(1):5337.
-
A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease. Cell Rep. 2021 09 28; 36(13):109754.
-
Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair. J Biol Chem. 2021 09; 297(3):101079.
-
The DNA-binding protein CST associates with the cohesin complex and promotes chromosome cohesion. J Biol Chem. 2021 09; 297(3):101026.
-
Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity. Life Sci Alliance. 2021 09; 4(9).
-
PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis. Nat Commun. 2021 06 08; 12(1):3444.