"Teniposide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
| Descriptor ID |
D013713
|
| MeSH Number(s) |
D09.408.348.800
|
| Concept/Terms |
Teniposide- Teniposide
- Demethyl Epipodophyllotoxin Thenylidine Glucoside
|
Below are MeSH descriptors whose meaning is more general than "Teniposide".
Below are MeSH descriptors whose meaning is more specific than "Teniposide".
This graph shows the total number of publications written about "Teniposide" by people in this website by year, and whether "Teniposide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Teniposide" by people in Profiles.
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Renal thrombotic microangiopathy and podocytopathy associated with the use of carfilzomib in a patient with multiple myeloma. BMC Nephrol. 2014 Sep 30; 15:156.
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Quantitation of gene-specific DNA damage by competitive PCR. Anal Biochem. 2002 Jul 15; 306(2):212-21.
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Topoisomerase II cleavable complex formation within DNA loop domains. Biochem Pharmacol. 2000 Jul 01; 60(1):101-9.
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Arrest of replication fork progression at sites of topoisomerase II-mediated DNA cleavage in human leukemia CEM cells incubated with VM-26. Biochemistry. 1997 May 13; 36(19):5739-48.
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DNA topoisomerase II isozymes involved in anticancer drug action and resistance. Adv Enzyme Regul. 1995; 35:265-81.