G Protein-Coupled Inwardly-Rectifying Potassium Channels
"G Protein-Coupled Inwardly-Rectifying Potassium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of inwardly-rectifying potassium channels that are activated by PERTUSSIS TOXIN sensitive G-PROTEIN-COUPLED RECEPTORS. GIRK potassium channels are primarily activated by the complex of GTP-BINDING PROTEIN BETA SUBUNITS and GTP-BINDING PROTEIN GAMMA SUBUNITS.
| Descriptor ID |
D051676
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| MeSH Number(s) |
D12.776.157.530.400.600.450.500 D12.776.543.550.450.750.450.500 D12.776.543.585.400.750.450.500
|
| Concept/Terms |
G Protein-Coupled Inwardly-Rectifying Potassium Channels- G Protein-Coupled Inwardly-Rectifying Potassium Channels
- G Protein Coupled Inwardly Rectifying Potassium Channels
- GIRK Potassium Channels
- Potassium Channels, GIRK
- G Protein-Activated Potassium Channels
- G Protein Activated Potassium Channels
- Kir3 Potassium Channels
- Potassium Channels, Kir3
|
Below are MeSH descriptors whose meaning is more general than "G Protein-Coupled Inwardly-Rectifying Potassium Channels".
Below are MeSH descriptors whose meaning is more specific than "G Protein-Coupled Inwardly-Rectifying Potassium Channels".
This graph shows the total number of publications written about "G Protein-Coupled Inwardly-Rectifying Potassium Channels" by people in this website by year, and whether "G Protein-Coupled Inwardly-Rectifying Potassium Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "G Protein-Coupled Inwardly-Rectifying Potassium Channels" by people in Profiles.
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Screening Technologies for Inward Rectifier Potassium Channels: Discovery of New Blockers and Activators. SLAS Discov. 2020 06; 25(5):420-433.
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Ethanol Dependence Abolishes Monoamine and GIRK (Kir3) Channel Inhibition of Orbitofrontal Cortex Excitability. Neuropsychopharmacology. 2017 Aug; 42(9):1800-1812.
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A fluorescent screening assay for identifying modulators of GIRK channels. J Vis Exp. 2012 Apr 24; (62).
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A real-time screening assay for GIRK1/4 channel blockers. J Biomol Screen. 2010 Dec; 15(10):1229-37.
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Effects of the abused inhalant toluene on ethanol-sensitive potassium channels expressed in oocytes. Brain Res. 2006 May 04; 1087(1):75-82.
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Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. Proc Natl Acad Sci U S A. 1997 Feb 04; 94(3):923-7.