"Vinca Alkaloids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.
| Descriptor ID |
D014748
|
| MeSH Number(s) |
D03.132.436.681.827 D03.633.100.473.402.681.827
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Vinca Alkaloids".
Below are MeSH descriptors whose meaning is more specific than "Vinca Alkaloids".
This graph shows the total number of publications written about "Vinca Alkaloids" by people in this website by year, and whether "Vinca Alkaloids" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Vinca Alkaloids" by people in Profiles.
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Vintafolide: a novel targeted agent for epithelial ovarian cancer. Future Oncol. 2014 Mar; 10(4):541-8.
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Olesoxime prevents microtubule-targeting drug neurotoxicity: selective preservation of EB comets in differentiated neuronal cells. Biochem Pharmacol. 2010 Sep 15; 80(6):884-94.
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Interaction of estramustine with tubulin isotypes. Biochemistry. 1997 Jan 28; 36(4):871-8.