"Clozapine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
| Descriptor ID |
D003024
|
| MeSH Number(s) |
D03.633.300.240.220
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Clozapine".
Below are MeSH descriptors whose meaning is more specific than "Clozapine".
This graph shows the total number of publications written about "Clozapine" by people in this website by year, and whether "Clozapine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 0 | 2 |
| 1995 | 2 | 0 | 2 |
| 1996 | 3 | 1 | 4 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 1 | 2 |
| 2001 | 1 | 0 | 1 |
| 2002 | 2 | 0 | 2 |
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2016 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Clozapine" by people in Profiles.
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Second-Generation Antipsychotics and Suicide: A Commentary. J Clin Psychiatry. 2021 07 20; 82(5).
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Clozapine utilization at the United States Veterans Health Administration: a descriptive report of prescribing patterns and patient characteristics among Operation Enduring Freedom/Operation Iraqi Freedom Veterans. Int Clin Psychopharmacol. 2020 11; 35(6):322-328.
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Social Stimuli Induce Activation of Oxytocin Neurons Within the Paraventricular Nucleus of the Hypothalamus to Promote Social Behavior in Male Mice. J Neurosci. 2020 03 11; 40(11):2282-2295.
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Divergent Prelimbic Cortical Pathways Interact with BDNF to Regulate Cocaine-seeking. J Neurosci. 2018 10 17; 38(42):8956-8966.
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Extended Amygdala to Ventral Tegmental Area Corticotropin-Releasing Factor Circuit Controls Binge Ethanol Intake. Biol Psychiatry. 2017 06 01; 81(11):930-940.
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Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking. Biol Psychiatry. 2015 Oct 01; 78(7):441-51.
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Designer receptors enhance memory in a mouse model of Down syndrome. J Neurosci. 2015 Jan 28; 35(4):1343-53.
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Consider ECT for treatment-resistant childhood schizophrenia. Am J Psychiatry. 2014 Sep; 171(9):1000.
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Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function. Biochem Pharmacol. 2009 Oct 01; 78(7):788-94.
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Haloperidol both prevents and reverses quinpirole-induced nonregulatory water intake, a putative animal model of psychogenic polydipsia. Psychopharmacology (Berl). 2008 Oct; 200(2):157-65.