"Interleukin-18" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.
| Descriptor ID |
D020382
|
| MeSH Number(s) |
D12.644.276.374.465.518 D12.776.467.374.465.518 D23.529.374.465.518
|
| Concept/Terms |
Interleukin-18- Interleukin-18
- Interleukin 18
- IFN-gamma-Inducing Factor
- IL-18
- Interferon-gamma Inducing Factor
- Inducing Factor, Interferon-gamma
- Interferon gamma Inducing Factor
- Interferon-gamma-Inducing Factor
- IFN-gamma Inducing Factor
- IFN gamma Inducing Factor
- Inducing Factor, IFN-gamma
- IL18
|
Below are MeSH descriptors whose meaning is more general than "Interleukin-18".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-18".
This graph shows the total number of publications written about "Interleukin-18" by people in this website by year, and whether "Interleukin-18" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 2 | 2 |
| 2020 | 2 | 0 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Interleukin-18" by people in Profiles.
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Urinary biomarkers predict progression and adverse outcomes of acute kidney injury in critical illness. Nephrol Dial Transplant. 2022 08 22; 37(9):1668-1678.
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Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. J Clin Invest. 2020 04 01; 130(4):1669-1682.
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Urine Markers of Kidney Tubule Cell Injury and Kidney Function Decline in SPRINT Trial Participants with CKD. Clin J Am Soc Nephrol. 2020 03 06; 15(3):349-358.
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The SPRINT trial suggests that markers of tubule cell function in the urine associate with risk of subsequent acute kidney injury while injury markers elevate after the injury. Kidney Int. 2019 08; 96(2):470-479.
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Fli-1 transcription factor regulates the expression of caspase-1 in lung pericytes. Mol Immunol. 2019 04; 108:1-7.
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IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-?B. J Immunol. 2017 10 01; 199(7):2333-2342.
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Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgery. Kidney Int. 2014 Feb; 85(2):431-8.
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Effects of interleukin-18 on cardiac fibroblast function and gene expression. Cytokine. 2011 Jan; 53(1):19-28.
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Clinical significance of IL-18 gene over-expression in AML. Leuk Res. 2002 Oct; 26(10):887-92.
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Detection and sequencing analysis of IL-18 expression in J(6-1_ leukemic cells. Leuk Res. 2001 Mar; 25(3):273-4.