"Leucine Zippers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.
| Descriptor ID |
D016350
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.520
|
| Concept/Terms |
Leucine Zippers- Leucine Zippers
- Leucine Zipper
- Zipper, Leucine
- Zippers, Leucine
|
Below are MeSH descriptors whose meaning is more general than "Leucine Zippers".
Below are MeSH descriptors whose meaning is more specific than "Leucine Zippers".
This graph shows the total number of publications written about "Leucine Zippers" by people in this website by year, and whether "Leucine Zippers" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 1 | 1 |
| 1996 | 1 | 0 | 1 |
| 1999 | 3 | 1 | 4 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leucine Zippers" by people in Profiles.
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Protein engineering in the development of functional hydrogels. Annu Rev Biomed Eng. 2010 Aug 15; 12:167-86.
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Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components. EMBO J. 2001 Jul 02; 20(13):3447-58.
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Identification of structural and functional domains in mixed lineage kinase dual leucine zipper-bearing kinase required for complex formation and stress-activated protein kinase activation. J Biol Chem. 2000 Mar 10; 275(10):7273-9.
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Correlation between knowledge-based and detailed atomic potentials: application to the unfolding of the GCN4 leucine zipper. Proteins. 1999 Jun 01; 35(4):447-52.
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The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate. J Biol Chem. 1999 Apr 09; 274(15):10195-202.
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Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Genomics. 1999 Feb 15; 56(1):111-20.
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TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors. J Immunol. 1999 Feb 01; 162(3):1559-65.
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The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures. J Biol Chem. 1996 Nov 22; 271(47):29612-8.
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In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB. Biochem J. 1995 Feb 01; 305 ( Pt 3):967-74.
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Multiple pathways of copy control of gamma replicon of R6K: mechanisms both dependent on and independent of cooperativity of interaction of tau protein with DNA affect the copy number. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6438-42.