"Perforin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
| Descriptor ID |
D054353
|
| MeSH Number(s) |
D12.776.543.695.875
|
| Concept/Terms |
Perforin- Perforin
- Lymphocyte Pore-Forming Protein
- Lymphocyte Pore Forming Protein
- Pore-Forming Protein, Lymphocyte
- Perforin 1
- Cytolysin
|
Below are MeSH descriptors whose meaning is more general than "Perforin".
Below are MeSH descriptors whose meaning is more specific than "Perforin".
This graph shows the total number of publications written about "Perforin" by people in this website by year, and whether "Perforin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Perforin" by people in Profiles.
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Sinonasal T-cell expression of cytotoxic mediators granzyme B and perforin is reduced in patients with chronic rhinosinusitis. Am J Rhinol Allergy. 2017 Nov 01; 31(6):352-356.
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Secretion of vascular endothelial growth factor by oral squamous cell carcinoma cells skews endothelial cells to suppress T-cell functions. Hum Immunol. 2009 Jun; 70(6):375-82.
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An assay for human hematopoietic stem cells based on transplantation into nonobese diabetic recombination activating gene-null perforin-null mice. Biol Blood Marrow Transplant. 2005 Jul; 11(7):487-94.
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Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. Arthritis Res Ther. 2005; 7(1):R30-7.
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Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome. J Pediatr. 2003 Mar; 142(3):292-6.
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The fraction of perforin-expressing HIV-specific CD8 T cells is a marker for disease progression in HIV infection. AIDS. 2002 Jul 26; 16(11):1497-501.
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Evidence for the involvement of Fas ligand and perforin in the induction of vascular leak syndrome. J Immunol. 1998 Sep 15; 161(6):3077-86.
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Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene. J Exp Med. 1993 Dec 01; 178(6):2225-30.