Pore Forming Cytotoxic Proteins
"Pore Forming Cytotoxic Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.
| Descriptor ID |
D052899
|
| MeSH Number(s) |
D12.776.543.695
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pore Forming Cytotoxic Proteins".
Below are MeSH descriptors whose meaning is more specific than "Pore Forming Cytotoxic Proteins".
This graph shows the total number of publications written about "Pore Forming Cytotoxic Proteins" by people in this website by year, and whether "Pore Forming Cytotoxic Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pore Forming Cytotoxic Proteins" by people in Profiles.
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Francisella novicida Two-Component System Response Regulator BfpR Modulates iglC Gene Expression, Antimicrobial Peptide Resistance, and Biofilm Production. Front Cell Infect Microbiol. 2020; 10:82.
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A prostate-specific antigen-activated channel-forming toxin as therapy for prostatic disease. J Natl Cancer Inst. 2007 Mar 07; 99(5):376-85.
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An assay for human hematopoietic stem cells based on transplantation into nonobese diabetic recombination activating gene-null perforin-null mice. Biol Blood Marrow Transplant. 2005 Jul; 11(7):487-94.
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Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. Arthritis Res Ther. 2005; 7(1):R30-7.
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Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome. J Pediatr. 2003 Mar; 142(3):292-6.
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The fraction of perforin-expressing HIV-specific CD8 T cells is a marker for disease progression in HIV infection. AIDS. 2002 Jul 26; 16(11):1497-501.
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Evidence for the involvement of Fas ligand and perforin in the induction of vascular leak syndrome. J Immunol. 1998 Sep 15; 161(6):3077-86.
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Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene. J Exp Med. 1993 Dec 01; 178(6):2225-30.