"alpha-Synuclein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synuclein that is a major component of LEWY BODIES that plays a role in neurodegeneration and neuroprotection.
| Descriptor ID |
D051844
|
| MeSH Number(s) |
D12.776.631.860.500 D12.776.637.500
|
| Concept/Terms |
alpha-Synuclein- alpha-Synuclein
- alpha Synuclein
- Non-AB Component of AD Amyloid Protein
- Non AB Component of AD Amyloid Protein
|
Below are MeSH descriptors whose meaning is more general than "alpha-Synuclein".
Below are MeSH descriptors whose meaning is more specific than "alpha-Synuclein".
This graph shows the total number of publications written about "alpha-Synuclein" by people in this website by year, and whether "alpha-Synuclein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 3 | 2 | 5 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 1 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 5 | 0 | 5 |
| 2020 | 0 | 1 | 1 |
| 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "alpha-Synuclein" by people in Profiles.
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Secretagogin is a Ca2+-dependent stress-responsive chaperone that may also play a role in aggregation-based proteinopathies. J Biol Chem. 2022 09; 298(9):102285.
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Restricting a-synuclein transport into mitochondria by inhibition of a-synuclein-VDAC complexation as a potential therapeutic target for Parkinson's disease treatment. Cell Mol Life Sci. 2022 Jun 19; 79(7):368.
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Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats. Neurobiol Dis. 2021 Mar; 150:105246.
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Molecular mechanism of olesoxime-mediated neuroprotection through targeting a-synuclein interaction with mitochondrial VDAC. Cell Mol Life Sci. 2020 Sep; 77(18):3611-3626.
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Secretagogin Binding Prevents a-Synuclein Fibrillation. Biochemistry. 2019 11 19; 58(46):4585-4589.
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Calpain in the cleavage of alpha-synuclein and the pathogenesis of Parkinson's disease. Prog Mol Biol Transl Sci. 2019; 167:107-124.
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Amphiphilic surface chemistry of fullerenols is necessary for inhibiting the amyloid aggregation of alpha-synuclein NACore. Nanoscale. 2019 Jun 20; 11(24):11933-11945.
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Probing Membrane Association of a-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern. Sci Rep. 2019 03 14; 9(1):4580.
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Cre-dependent AAV vectors for highly targeted expression of disease-related proteins and neurodegeneration in the substantia nigra. FASEB J. 2018 08; 32(8):4420-4427.
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Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide. Phys Chem Chem Phys. 2017 Nov 22; 19(45):30627-30635.