"Pentoxifylline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
| Descriptor ID |
D010431
|
| MeSH Number(s) |
D03.633.100.759.758.824.651.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Pentoxifylline".
Below are MeSH descriptors whose meaning is more specific than "Pentoxifylline".
This graph shows the total number of publications written about "Pentoxifylline" by people in this website by year, and whether "Pentoxifylline" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 0 | 2 |
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pentoxifylline" by people in Profiles.
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Enhancement of sperm motility using pentoxifylline and platelet-activating factor. Methods Mol Biol. 2013; 927:241-5.
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Is pentoxifylline safe and effective in patients with amyotrophic lateral sclerosis? Nat Clin Pract Neurol. 2006 Jul; 2(7):364-5.
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Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism. Toxicol Sci. 2005 Mar; 84(1):139-48.
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Inhibition of matrix metalloproteinase activity attenuates tenascin-C production and calcification of implanted purified elastin in rats. Am J Pathol. 2000 Sep; 157(3):885-93.
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Protection by pentoxifylline against normothermic liver ischemia/reperfusion in rats. Transplantation. 1995 Jun 15; 59(11):1537-41.
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The effect of pentoxifylline on acid-induced alveolar epithelial injury. Anesthesiology. 1995 Feb; 82(2):531-41.
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Ultrastructural correlates of liver graft failure from storage injury: studies of graft protection by Carolina rinse solution and pentoxifylline. Transplant Proc. 1993 Feb; 25(1 Pt 2):1620-4.
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Inhibition of tumor necrosis factor release from cultured rat Kupffer cells by agents that reduce graft failure from storage injury. Transplant Proc. 1993 Feb; 25(1 Pt 2):1631-2.
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Protection by pentoxifylline against graft failure from storage injury after orthotopic rat liver transplantation with arterialization. Transpl Int. 1992; 5 Suppl 1:S345-50.
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Influence of pentoxifylline on steady-state theophylline serum concentrations from sustained-release formulations. Pharmacotherapy. 1990; 10(6):383-6.