Masahiro Kono

Title
InstitutionMedical University of South Carolina
DepartmentOphthalmology
AddressP.O. Box MSC 676
714
167 Ashley Ave.
Phone843-792-6676
ORCID ORCID Icon0000-0001-7377-1664 Additional info
vCardDownload vCard

    Collapse Biography 
    Collapse education and training
    Massachusetts Institute of Technology, Cambridge, MABS06/1986Chemistry
    University of Illinois at Urbana-Champaign, Urbana, ILPhD10/1994Biophysics

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rahman B, Anderson DMG, Chen C, Liu J, Migas LG, Van de Plas R, Schey KL, Kono M, Fan J, Koutalos Y. Sphingolipid Levels and Processing of the Retinyl Chromophore in the Retina of a Mouse Model of Niemann-Pick Disease. Invest Ophthalmol Vis Sci. 2024 Dec 02; 65(14):24. PMID: 39661357; PMCID: PMC11640910.
      Citations:    
    2. Chen C, Adler L, Milliken C, Rahman B, Kono M, Perry LP, Gonzalez-Fernandez F, Koutalos Y. The First Steps of the Visual Cycle in Human Rod and Cone Photoreceptors. Invest Ophthalmol Vis Sci. 2024 Jul 01; 65(8):9. PMID: 38958967; PMCID: PMC11223620.
      Citations:    
    3. Luo DG, Silverman D, Frederiksen R, Adhikari R, Cao LH, Oatis JE, Kono M, Cornwall MC, Yau KW, Luo DG, Silverman D, Frederiksen R, Adhikari R, Cao LH, Oatis JE, Kono M, Cornwall MC, Yau KW. Apo-Opsin and Its Dark Constitutive Activity across Retinal Cone Subtypes. Curr Biol. 2020 12 21; 30(24):4921-4931.e5. PMID: 33065015; PMCID: PMC8561704.
      Citations:    
    4. Chen C, Kono M, Koutalos Y, Chen C, Kono M, Koutalos Y. Photooxidation mediated by 11-cis and all-trans retinal in single isolated mouse rod photoreceptors. Photochem Photobiol Sci. 2020 Oct 14; 19(10):1300-1307. PMID: 32812970; PMCID: PMC7559207.
      Citations:    
    5. Hanneken A, Neikirk T, Johnson J, Kono M, Hanneken A, Neikirk T, Johnson J, Kono M. Biochemical Measurements of Free Opsin in Macular Degeneration Eyes: Examining the 11-CIS Retinal Deficiency Hypothesis of Delayed Dark Adaptation (An American Ophthalmological Society Thesis). Trans Am Ophthalmol Soc. 2017 Aug; 115:T1. PMID: 28900371; PMCID: PMC5572981.
      Citations:    
    6. Crouch RK, Koutalos Y, Kono M, Schey K, Ablonczy Z, Crouch RK, Koutalos Y, Kono M, Schey K, Ablonczy Z. A2E and Lipofuscin. Prog Mol Biol Transl Sci. 2015; 134:449-63. PMID: 26310170.
      Citations:    
    7. Kono M, Kono M. Cone Health and Retinoids. Prog Mol Biol Transl Sci. 2015; 134:465-76. PMID: 26310171.
      Citations:    
    8. Tam BM, Noorwez SM, Kaushal S, Kono M, Moritz OL, Tam BM, Noorwez SM, Kaushal S, Kono M, Moritz OL. Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosa. J Neurosci. 2014 Oct 01; 34(40):13336-48. PMID: 25274813; PMCID: PMC4180472.
      Citations:    
    9. Isayama T, Chen Y, Kono M, Fabre E, Slavsky M, DeGrip WJ, Ma JX, Crouch RK, Makino CL, Isayama T, Chen Y, Kono M, Fabre E, Slavsky M, DeGrip WJ, Ma JX, Crouch RK, Makino CL. Coexpression of three opsins in cone photoreceptors of the salamander Ambystoma tigrinum. J Comp Neurol. 2014 Jul 01; 522(10):2249-65. PMID: 24374736; PMCID: PMC3997598.
      Citations:    
    10. Crouch RK, Kono M, Crouch RK, Kono M. Ligand control of g protein-coupled receptor activity: new insights. Chem Biol. 2014 Mar 20; 21(3):309-10. PMID: 24655920.
      Citations:    
    11. Bandyopadhyay M, Kono M, Rohrer B, Bandyopadhyay M, Kono M, Rohrer B. Explant cultures of Rpe65-/- mouse retina: a model to investigate cone opsin trafficking. Mol Vis. 2013; 19:1149-57. PMID: 23734084; PMCID: PMC3669539.
      Citations:    
    12. Tang PH, Kono M, Koutalos Y, Ablonczy Z, Crouch RK, Tang PH, Kono M, Koutalos Y, Ablonczy Z, Crouch RK. New insights into retinoid metabolism and cycling within the retina. Prog Retin Eye Res. 2013 Jan; 32:48-63. PMID: 23063666; PMCID: PMC3746031.
      Citations:    
    13. Fan J, Crouch RK, Kono M, Fan J, Crouch RK, Kono M. Light prevents exogenous 11-cis retinal from maintaining cone photoreceptors in chromophore-deficient mice. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2412-6. PMID: 21228385; PMCID: PMC3081252.
      Citations:    
    14. Kono M, Crouch RK, Kono M, Crouch RK. Probing human red cone opsin activity with retinal analogues. J Nat Prod. 2011 Mar 25; 74(3):391-4. PMID: 21314100; PMCID: PMC3064742.
      Citations:    
    15. Kono M, Crouch RK, Kono M, Crouch RK. In vitro assays of rod and cone opsin activity: retinoid analogs as agonists and inverse agonists. Methods Mol Biol. 2010; 652:85-94. PMID: 20552423; PMCID: PMC3694563.
      Citations:    
    16. Kono M, Kono M. Assays for inverse agonists in the visual system. Methods Enzymol. 2010; 485:213-24. PMID: 21050919; PMCID: PMC3697084.
      Citations:    
    17. Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K, Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, M?ller DJ, Palczewski K. Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 2009 May 26; 48(20):4294-304. PMID: 19348429; PMCID: PMC2710298.
      Citations:    
    18. Ala-Laurila P, Cornwall MC, Crouch RK, Kono M, Ala-Laurila P, Cornwall MC, Crouch RK, Kono M. The action of 11-cis-retinol on cone opsins and intact cone photoreceptors. J Biol Chem. 2009 Jun 12; 284(24):16492-16500. PMID: 19386593; PMCID: PMC2713570.
      Citations:    
    19. Kono M, Goletz PW, Crouch RK, Kono M, Goletz PW, Crouch RK. 11-cis- and all-trans-retinols can activate rod opsin: rational design of the visual cycle. Biochemistry. 2008 Jul 15; 47(28):7567-71. PMID: 18563917; PMCID: PMC2561911.
      Citations:    
    20. McKee TD, Lewis MR, Kono M, McKee TD, Lewis MR, Kono M. Engineering a "steric doorstop" in rhodopsin: converting an inverse agonist to an agonist. Biochemistry. 2007 Oct 30; 46(43):12248-52. PMID: 17918963.
      Citations:    
    21. Lewis MR, Kono M, Lewis MR, Kono M. Rhodopsin deactivation is affected by mutations of Tyrl91. Photochem Photobiol. 2006 Nov-Dec; 82(6):1442-6. PMID: 16906791.
      Citations:    
    22. Isayama T, Chen Y, Kono M, Degrip WJ, Ma JX, Crouch RK, Makino CL. Differences in the pharmacological activation of visual opsins. Vis Neurosci. 2006 Nov-Dec; 23(6):899-908. PMID: 17266782.
      Citations:    
    23. Ablonczy Z, Kono M, Knapp DR, Crouch RK, Ablonczy Z, Kono M, Knapp DR, Crouch RK. Palmitylation of cone opsins. Vision Res. 2006 Dec; 46(27):4493-501. PMID: 16989884; PMCID: PMC2025682.
      Citations:    
    24. Kono M, Kono M. Constitutive activity of a UV cone opsin. FEBS Lett. 2006 Jan 09; 580(1):229-32. PMID: 16368093; PMCID: PMC1661692.
      Citations:    
    25. Sutton RB, Vishnivetskiy SA, Robert J, Hanson SM, Raman D, Knox BE, Kono M, Navarro J, Gurevich VV, Sutton RB, Vishnivetskiy SA, Robert J, Hanson SM, Raman D, Knox BE, Kono M, Navarro J, Gurevich VV. Crystal structure of cone arrestin at 2.3A: evolution of receptor specificity. J Mol Biol. 2005 Dec 16; 354(5):1069-80. PMID: 16289201.
      Citations:    
    26. Kefalov VJ, Estevez ME, Kono M, Goletz PW, Crouch RK, Cornwall MC, Yau KW. Breaking the covalent bond--a pigment property that contributes to desensitization in cones. Neuron. 2005 Jun 16; 46(6):879-90. PMID: 15953417; PMCID: PMC2885911.
      Citations:    
    27. Kono M, Crouch RK, Oprian DD, Kono M, Crouch RK, Oprian DD. A dark and constitutively active mutant of the tiger salamander UV pigment. Biochemistry. 2005 Jan 18; 44(2):799-804. PMID: 15641808.
      Citations:    
    28. Kim JM, Altenbach C, Kono M, Oprian DD, Hubbell WL, Khorana HG, Kim JM, Altenbach C, Kono M, Oprian DD, Hubbell WL, Khorana HG. Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge. Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34):12508-13. PMID: 15306683; PMCID: PMC515088.
      Citations:    
    29. Das J, Crouch RK, Ma JX, Oprian DD, Kono M, Das J, Crouch RK, Ma JX, Oprian DD, Kono M. Role of the 9-methyl group of retinal in cone visual pigments. Biochemistry. 2004 May 11; 43(18):5532-8. PMID: 15122919.
      Citations:    
    30. Darden AG, Wu BX, Znoiko SL, Hazard ES, Kono M, Crouch RK, Ma JX, Darden AG, Wu BX, Znoiko SL, Hazard ES, Kono M, Crouch RK, Ma JX. A novel Xenopus SWS2, P434 visual pigment: structure, cellular location, and spectral analyses. Mol Vis. 2003 May 16; 9:191-9. PMID: 12764253.
      Citations: 3     Fields:    Translation:AnimalsCells
    31. Ma J, Znoiko S, Othersen KL, Ryan JC, Das J, Isayama T, Kono M, Oprian DD, Corson DW, Cornwall MC, Cameron DA, Harosi FI, Makino CL, Crouch RK. A visual pigment expressed in both rod and cone photoreceptors. Neuron. 2001 Nov 08; 32(3):451-61. PMID: 11709156.
      Citations: 54     Fields:    Translation:AnimalsCells
    32. Ablonczy Z, Kono M, Crouch RK, Knapp DR, Ablonczy Z, Kono M, Crouch RK, Knapp DR. Mass spectrometric analysis of integral membrane proteins at the subnanomolar level: application to recombinant photopigments. Anal Chem. 2001 Oct 15; 73(20):4774-9. PMID: 11681450.
      Citations:    
    33. Ma JX, Kono M, Xu L, Das J, Ryan JC, Hazard ES, Oprian DD, Crouch RK. Salamander UV cone pigment: sequence, expression, and spectral properties. Vis Neurosci. 2001 May-Jun; 18(3):393-9. PMID: 11497415.
      Citations:    
    34. Yu H, Kono M, Oprian DD. State-dependent disulfide cross-linking in rhodopsin. Biochemistry. 1999 Sep 14; 38(37):12028-32. PMID: 10508406.
      Citations:    
    35. Struthers M, Yu H, Kono M, Oprian DD. Tertiary interactions between the fifth and sixth transmembrane segments of rhodopsin. Biochemistry. 1999 May 18; 38(20):6597-603. PMID: 10350478.
      Citations:    
    36. Kono M, Yu H, Oprian DD. Disulfide bond exchange in rhodopsin. Biochemistry. 1998 Feb 03; 37(5):1302-5. PMID: 9477956.
      Citations:    
    37. Yu H, Kono M, McKee TD, Oprian DD. A general method for mapping tertiary contacts between amino acid residues in membrane-embedded proteins. Biochemistry. 1995 Nov 21; 34(46):14963-9. PMID: 7578109.
      Citations:    
    38. Govindjec R, Kono M, Balashov SP, Imasheva E, Sheves M, Ebrey TG. Effects of substitution of tyrosine 57 with asparagine and phenylalanine on the properties of bacteriorhodopsin. Biochemistry. 1995 Apr 11; 34(14):4828-38. PMID: 7718589.
      Citations:    
    39. Lukashev EP, Govindjee R, Kono M, Ebrey TG, Sugiyama Y, Mukohata Y. pH dependence of the absorption spectra and photochemical transformations of the archaerhodopsins. Photochem Photobiol. 1994 Jul; 60(1):69-75. PMID: 8073078.
      Citations:    
    40. Balashov SP, Govindjee R, Kono M, Imasheva E, Lukashev E, Ebrey TG, Crouch RK, Menick DR, Feng Y. Effect of the arginine-82 to alanine mutation in bacteriorhodopsin on dark adaptation, proton release, and the photochemical cycle. Biochemistry. 1993 Oct 05; 32(39):10331-43. PMID: 8399176.
      Citations: 49     Fields:    Translation:Cells
    41. Kono M, Misra S, Ebrey TG. pH dependence of light-induced proton release by bacteriorhodopsin. FEBS Lett. 1993 Sep 27; 331(1-2):31-4. PMID: 8405405.
      Citations:    
    42. Liu SY, Kono M, Ebrey TG. Effect of pH buffer molecules on the light-induced currents from oriented purple membrane. Biophys J. 1991 Jul; 60(1):204-16. PMID: 1883939; PMCID: PMC1260052.
      Citations:    
    Kono's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (150)
    Explore
    _
    Co-Authors (6)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _