17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species.

17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species. Mol Cancer Ther. 2010 May; 9(5):1378-95.

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subject areas

Antineoplastic Combined Chemotherapy Protocols
Apoptosis
Benzoquinones
Calcium
Carcinoma
Ceramides
Down-Regulation
Drug Evaluation, Preclinical
Drug Interactions
Gastrointestinal Neoplasms
HCT116 Cells
Heat-Shock Proteins
Hep G2 Cells
Humans
Lactams, Macrocyclic
MAP Kinase Kinase 1
MAP Kinase Kinase 2
Protein Kinase Inhibitors
Reactive Oxygen Species
Signal Transduction
Tumor Cells, Cultured

authors with profiles

Christina Voelkel Johnson