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Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma.
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Thymic pathogenicity of an HIV-1 envelope is associated with increased CXCR4 binding efficiency and V5-gp41-dependent activity, but not V1/V2-associated CD4 binding efficiency and viral entry.
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Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma.
Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma. J Clin Invest. 2017 Mar 01; 127(3):830-842.
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PubMed
subject areas
Animals
Carcinoma, Hepatocellular
E2F1 Transcription Factor
E2F3 Transcription Factor
Gene Dosage
Genes, Neoplasm
Humans
Liver Neoplasms
Mice
Mice, Knockout
Neoplasm Proteins
authors with profiles
Gustavo Leone
Lindsey Kent
Christopher S Koivisto