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Bcl-2 and Bcl-xL mediate resistance to receptor tyrosine kinase-targeted therapy in lung and gastric cancer.

Bcl-2 and Bcl-xL mediate resistance to receptor tyrosine kinase-targeted therapy in lung and gastric cancer. Anticancer Drugs. 2017 11; 28(10):1141-1149.

View in: PubMed

subject areas
  • Aniline Compounds
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols
  • bcl-X Protein
  • Cell Line, Tumor
  • Drug Resistance, Neoplasm
  • Drug Synergism
  • Humans
  • Lung Neoplasms
  • Male
  • MAP Kinase Signaling System
  • Mice
  • Mice, Nude
  • Molecular Targeted Therapy
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins c-akt
  • Proto-Oncogene Proteins c-bcl-2
  • Random Allocation
  • Stomach Neoplasms
  • Sulfonamides
  • Up-Regulation
  • Xenograft Model Antitumor Assays

authors with profiles
  • Bo Cen
  • Ying Xiong