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    • Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.
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Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.

Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer. Oncotarget. 2015 Dec 29; 6(42):44509-22.

View in: PubMed

subject areas
  • Animals
  • Antineoplastic Agents
  • Carcinoma, Pancreatic Ductal
  • Cell Survival
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Forkhead Transcription Factors
  • Genes, BRCA1
  • Genes, p53
  • Genes, ras
  • Genetic Predisposition to Disease
  • Heterocyclic Compounds, 3-Ring
  • Janus Kinase 2
  • Lymphocytes, Tumor-Infiltrating
  • Mice, Transgenic
  • Molecular Targeted Therapy
  • Mutation
  • Pancreatic Neoplasms
  • Phenotype
  • Phosphorylation
  • Protein Kinase Inhibitors
  • Signal Transduction
  • STAT5 Transcription Factor
  • Time Factors
  • T-Lymphocytes, Regulatory
  • Tumor Burden

authors with profiles
  • Michael C Ostrowski