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LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria.

LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria. J Pharmacol Exp Ther. 2013 Jan; 344(1):167-78.

View in: PubMed

subject areas
  • Animals
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Apoptosis
  • Benzimidazoles
  • Blotting, Western
  • Carbocyanines
  • Cell Death
  • Cell Line, Tumor
  • Ceramides
  • Chromatography, High Pressure Liquid
  • Coloring Agents
  • Cytochromes c
  • Deoxycytidine
  • Female
  • Membrane Potential, Mitochondrial
  • Mice
  • Mice, Nude
  • Mitochondria
  • Oxygen Consumption
  • Pancreatic Neoplasms
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Spectrum Analysis
  • Xenograft Model Antitumor Assays

authors with profiles
  • Zdzislaw Szulc
  • Craig Cano Beeson
  • Richard R. Drake
  • James S. Norris
  • Joseph C. Cheng
  • Xiang Liu