"ADAMTS5 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE, and may be involved in the destruction of aggrecan in ARTHRITIS.
| Descriptor ID |
D000071116
|
| MeSH Number(s) |
D08.811.277.656.675.374.102.500.875 D09.400.430.500.500.875 D12.776.395.033.500.875 D12.776.860.300.085.875
|
| Concept/Terms |
ADAMTS5 Protein- ADAMTS5 Protein
- A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 Protein
- ADAMTS11 Protein
- Aggrecanase-2
- Aggrecanase 2
- ADAMTS-5 Protein
- ADAMTS 5 Protein
- ADAMTS5 Protease
|
Below are MeSH descriptors whose meaning is more general than "ADAMTS5 Protein".
Below are MeSH descriptors whose meaning is more specific than "ADAMTS5 Protein".
This graph shows the total number of publications written about "ADAMTS5 Protein" by people in this website by year, and whether "ADAMTS5 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "ADAMTS5 Protein" by people in Profiles.
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Adamts5-/- Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies. Arterioscler Thromb Vasc Biol. 2019 10; 39(10):2067-2081.
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Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves. J Mol Cell Cardiol. 2013 Jul; 60:50-9.
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Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease. Dev Biol. 2011 Sep 01; 357(1):152-64.