Poly (ADP-Ribose) Polymerase-1
"Poly (ADP-Ribose) Polymerase-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A poly(ADP-ribose) polymerase that contains two ZINC FINGERS in its N-terminal DNA-binding region. It modifies NUCLEAR PROTEINS involved in chromatin architecture and BASE EXCISION REPAIR with POLY ADENOSINE DIPHOSPHATE RIBOSE.
| Descriptor ID |
D000071137
|
| MeSH Number(s) |
D08.811.913.400.725.115.690.420
|
| Concept/Terms |
Poly (ADP-Ribose) Polymerase-1- Poly (ADP-Ribose) Polymerase-1
- Poly (ADP-Ribose) Synthase-1
- PARP1 Protein
- PARP-1 Protein
- PARP 1 Protein
- NAD+ ADP-ribosyltransferase-1
- NAD+ ADP ribosyltransferase 1
|
Below are MeSH descriptors whose meaning is more general than "Poly (ADP-Ribose) Polymerase-1".
Below are MeSH descriptors whose meaning is more specific than "Poly (ADP-Ribose) Polymerase-1".
This graph shows the total number of publications written about "Poly (ADP-Ribose) Polymerase-1" by people in this website by year, and whether "Poly (ADP-Ribose) Polymerase-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Poly (ADP-Ribose) Polymerase-1" by people in Profiles.
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Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa. Elife. 2021 06 29; 10.
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PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons. Neurochem Int. 2021 Sep; 148:105077.
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Homologous Recombination-Mediated DNA Repair and Implications for Clinical Treatment of Repair Defective Cancers. Methods Mol Biol. 2019; 1999:3-29.
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Dopamine Triggers CTCF-Dependent Morphological and Genomic Remodeling of Astrocytes. J Neurosci. 2018 05 23; 38(21):4846-4858.
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3-Hydroxyterphenyllin, a natural fungal metabolite, induces apoptosis and S phase arrest in human ovarian carcinoma cells. Int J Oncol. 2017 Apr; 50(4):1392-1402.
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BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells. Oncotarget. 2017 Jan 31; 8(5):8670-8678.
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The role of base excision repair in pathogenesis of breast cancer in the Polish population. Mol Carcinog. 2016 12; 55(12):1899-1914.