"RNA Caps" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nucleic acid structures found on the 5' end of eukaryotic cellular and viral messenger RNA and some heterogeneous nuclear RNAs. These structures, which are positively charged, protect the above specified RNAs at their termini against attack by phosphatases and other nucleases and promote mRNA function at the level of initiation of translation. Analogs of the RNA caps (RNA CAP ANALOGS), which lack the positive charge, inhibit the initiation of protein synthesis.
| Descriptor ID |
D012315
|
| MeSH Number(s) |
D03.633.100.759.646.454.700 D13.444.735.544.500 D13.695.667.454.700 D13.695.827.426.700
|
| Concept/Terms |
RNA Caps- RNA Caps
- Caps, RNA
- 5' Capped RNA
- RNA, 5' Capped
- 5' mRNA Cap Structure
|
Below are MeSH descriptors whose meaning is more general than "RNA Caps".
Below are MeSH descriptors whose meaning is more specific than "RNA Caps".
This graph shows the total number of publications written about "RNA Caps" by people in this website by year, and whether "RNA Caps" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2008 | 3 | 0 | 3 |
| 2010 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 2 | 0 | 2 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "RNA Caps" by people in Profiles.
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Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9. ACS Chem Biol. 2022 06 17; 17(6):1460-1471.
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Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis. Structure. 2022 05 05; 30(5):721-732.e4.
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Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation. Nat Chem Biol. 2021 05; 17(5):615-623.
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Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect. ACS Chem Biol. 2021 02 19; 16(2):334-343.
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Pat1 activates late steps in mRNA decay by multiple mechanisms. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23512-23517.
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Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis. Nat Commun. 2018 03 20; 9(1):1152.
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Application of a Schizosaccharomyces pombe Edc1-fused Dcp1-Dcp2 decapping enzyme for transcription start site mapping. RNA. 2018 02; 24(2):251-257.
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Structural basis of mRNA-cap recognition by Dcp1-Dcp2. Nat Struct Mol Biol. 2016 Nov; 23(11):987-994.
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Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition. RNA. 2011 Feb; 17(2):278-90.
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A split active site couples cap recognition by Dcp2 to activation. Nat Struct Mol Biol. 2010 Sep; 17(9):1096-101.