"Self Tolerance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The normal lack of the ability to produce an immunological response to autologous (self) antigens. A breakdown of self tolerance leads to autoimmune diseases. The ability to recognize the difference between self and non-self is the prime function of the immune system.
| Descriptor ID |
D017634
|
| MeSH Number(s) |
G12.535.425.800
|
| Concept/Terms |
Self Tolerance- Self Tolerance
- Self Tolerances
- Tolerance, Self
- Tolerances, Self
|
Below are MeSH descriptors whose meaning is more general than "Self Tolerance".
Below are MeSH descriptors whose meaning is more specific than "Self Tolerance".
This graph shows the total number of publications written about "Self Tolerance" by people in this website by year, and whether "Self Tolerance" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Self Tolerance" by people in Profiles.
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The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation. Nat Commun. 2019 01 21; 10(1):354.
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Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury. Circulation. 2015 Mar 31; 131(13):1171-80.
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GM-CSF-induced CD11c+CD8a--dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis. Int Immunol. 2009 Mar; 21(3):269-82.
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Effect of CD4+CD25+ and CD4+CD25- T regulatory cells on the generation of cytolytic T cell response to a self but human tumor-associated epitope in vitro. J Immunol. 2006 Jan 15; 176(2):984-90.
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Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease. J Immunol. 2003 Feb 15; 170(4):2195-204.
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Induction of autoimmunity in a transgenic model of B cell receptor peripheral tolerance: changes in coreceptors and B cell receptor-induced tyrosine-phosphoproteins. J Immunol. 1999 Nov 15; 163(10):5287-97.
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Autoimmunity and tolerance in Ig-transgenic mice: murine SLE as a model to study B cell tolerance. Int Rev Immunol. 1994; 11(4):305-20.